Jinsheng Zhang

Jinsheng Zhang

(313) 577-0066 (Office) (313) 577-0190 (Lab)

313-577-6318 (fax)

jinzhang@med.wayne.edu

Jinsheng Zhang

Position Title

Professor
Research Educator track, full time
Associate Chair for Research
Director - Laboratory of Tinnitus and Auditory Neuroscience Research
 

Narrative Bio

Jinsheng Zhang received a Ph.D. degree in auditory neurophysiology at University of Fribourg in Switzerland in 1997. He is a tenured full Professor in the Department of Otolaryngology, School of Medicine and the Department of Communication Sciences & Disorders, College of Liberal Arts and Sciences, Wayne State University. He is the Vice Chair for Research and Research Director of the Department of Otolaryngology at Wayne State University School of Medicine. He is the director of the Laboratories of Tinnitus and Auditory Neuroscience Research. His research interests encompass neural mechanisms underlying noise- and blast-induced tinnitus, tinnitus-related traumatic brain injury, brain neuromodulation with sound, electrical stimulation, light and pharmacological agents to treat tinnitus and related neurological disorders, multi-structure electrophysiological recordings, cross-modality neural plasticity, and auditory prostheses. Over the years, he has served as principal investigator on NIH-, DOD-, NSF-, and private agencies-funded projects, and has nearly 90 publications, holds 3 patents, and has trained nearly 50 residents, postdocs, Ph.D. students and other trainees. He was invited to speak at several international tinnitus conferences including Asian-Pacific International Tinnitus Symposium, International Tinnitus Seminar, Tinnitus Research Initiative International Meeting, International Association of Physician in Audiology, and DOD International Tinnitus Conference. He serves as reviewers for a number of scientific journals, as well as federal, international and private funding agencies. He also serves as Associate Editor of JMIHI, Journal of Medical Imaging and Health Informatics, guest associate editor of the Journal of American Audiology, board officer of the Lions Hearing Center of Michigan, Scientific advisory committee of the XIth International Tinnitus Seminars in Berlin, and the Scientific Research Advisory Committee of the American Tinnitus Association. He served as the Chair of the Scientific Advisory Committee (consisting of international tinnitus experts) of the American Tinnitus Association. He also organized a special issue on tinnitus, with contributions from experts around the world. This issue appears in the journal Frontiers in Neurology. He is currently serving on the Board of the American Tinnitus Association. He and Dr. Grant Searchfield are editing a volume: The Behavioral Neuroscience of Tinnitus, published by Springer.

In teaching, Dr. Zhang offers two courses each year, which are Anatomy and Physiology of the Auditory System (AUD 6400), & Psychoacoustics (AUD 7410) in the Department of Communication Sciences and Disorders. He also teaches basic science courses for residents and fellows in the Department of Otolaryngology. He participates in teaching Advanced Neurophysiology (PSL 7660) offered to Ph.D. students in the School of Medicine.

Education
1985-1988   M.S. in Physiology, Hebei Normal University, China
1994-1997   Ph.D. in Auditory Neurophysiology, University of Fribourg, Switzerland
1998-2001   
M.S. courses in Electronics and Computer Control System, Wayne State University
1997-2000  
Postdoctoral training, Department of Otolaryngology, Wayne State University

Faculty Appointments
2016-present   Professor, Department of Biomedical Engineering, Wayne State University College of Engineering.
2013-present   Professor, Department of Biology, University of Windsor, Canada.
2012-present  Professor, Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine.
2012-present  Professor, Department of Communication Sciences and Disorders, College of Liberal Arts & Sciences, Wayne State University.
2006-2012       Associate Professor, Department of Communication Sciences and Disorders, College of Liberal Arts & Sciences, Wayne State University.
2005-2012       Associate Professor, Department of Otolaryngology- Head and Neck Surgery, Wayne State University School of Medicine.
2000-2005       Assistant Professor, Department of Otolaryngology- Head and Neck Surgery, Wayne State University School of Medicine.
1990-1993       
Instructor, Department of Biology, Hebei Normal University, Shijiazhuang, China.

Other Professional Appointments
2007-Present  Associate Faculty in Department of Physiology, Wayne State University School of Medicine.
1997-2000       
Research Associate, Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine.
1994-1997     
  Research Assistant, Institute of Physiology, University of Fribourg, Switzerland.
1988-1990       
Teaching Assistant, Biology Department, Hebei Normal University, China.

Service
2013-2014:      Conference Scientific Advisor Committee & Conference Panel Chair, The XI International Tinnitus Seminar (ITS), Berlin, Germany.
2013-present: External Relations Committee, The Association for Research in Otolaryngology (ARO), USA
2013-present  VA grant reviewer, Department of Veterans Affairs, USA
2014-2015:      Scientific Advisory Committee, The 9th TRI Intl Tinnitus Conference – Tinnitus from Cochlea to Brain and Back. Ann Arbor, USA
2015                Scientific Advisory Committee, The 9th International TRI Conference on tinnitus.
2015-2017:      Chair, Scientific Advisory Committee, The American Tinnitus Association (ATA). Portland, Oregon, USA. 
2017-2018:      Past-Chair, Scientific Advisory Committee, The American Tinnitus Association (ATA). Portland, Oregon, USA.
2015-2020:      Board of Directors, The American Tinnitus Association (ATA). Portland, Oregon, USA. July 1, 2015-June 30th, 2017
2018-present: Grant reviewer, UK-AOHL
2018-present: Grant reviewer, The Netherland - TOP (Government Funding Agency)
2018-present: Grant reviewer, UK – Action on Hearing Loss
2018-present: Grant reviewer, UK – Medical Research Council (MRC)

Editorial Board:
2008                Guest Associate Editor, Journal of American Audiology
2014–2015      Editor, Special Issue on Tinnitus, Frontiers in Neurology, Otology Section
2014–2016      Associate Editor, JMIHI, Journal of Medical Imaging and Health Informatics

Journal Reviewer:
EBR - Experimental Brain Research
MCBI - Molecular and Cellular Biochemistry
Audiology and Neuro-Otology
Journal of Neuroscience (Society for Neuroscience)
Hearing Research
Journal of Orofacial Pain
JNR - Journal of Neuroscience Research.
Journal of American Audiology
Journal of Controlled Release
Growth Hormones & IGF Research
Ear and Hearing
Neuroscience
Physiology & Behavior
Journal of Neuroinflammation
Physiology & Behavior
Neuroscience & Biobehavioral Reviews
Brain Research
Journal of American Academy of Audiology
PLOS ONE
JARO, Journal of Associate for Research in Otolaryngology
Journal of Neurophysiology
Journal of Neuroscience Methods
Journal of Neural Engineering
Cellular Physiology and Biochemistry
Science-Translational Medicine 
Trends in Hearing 
Neuromodulation Technology at the Neural Interface 
JAMA-Otolaryngology
JoVE

Professional Memberships:
Association for Research in Otolaryngology (ARO)
Member, American Tinnitus Association (ATA)
Society for Neuroscience (SFN) 

Office Address

Wayne State University - School of Medicine
Otolaryngology
Lande, 268
550 E. Canfield
Detroit, MI 48201

Links of Interest

NIH Biosketch

Research Highlights

Dr. Zhang's ResearchGate
Podcast on Neuromodulation to Suppress Tinnitus (or Youtube)
Auditory Cortex Electrical Stimulation Suppresses Tinnitus in Rats
Blast-Induced Tinnitus - MRI Study
Blast-Induced Tinnitus - MEMRI Study
Dr. Zhang's Team Develop Behavioral Tool for Understanding Tinnitus in Rats & Article
Postdoc Dr. Hao Luo Receives a New Grant Award on Tinnitus Research via Cochlear Stimulation

Other Activities

Drs. Zhang and Norena Hosted a Special Issue: Tinnitus - An Attempt to Confront the Diverse Models
Dr. Zhang will lead scientific committee for tinnitus association
Report by Dr. Zhang as ATA-SAC chair: Research and Treatment Developments from the 9th International Tinnitus Research Initiative Tinnitus Conference
Participation in DOD-Hearing Center of Excellence's Pharmaceutical Interventions for Hearing Loss: Noise Committee
Hyperacusis-Related Research Activity
Dr. Zhang to address worldwide conference on tinnitus

In the News

Preventing noise-induced hearing loss, tinnitus in soldiers
Congress Mandates Better Reporting of Tinnitus Among United States Military
The Noise in Your Head
The Sound That Comes From Nowhere
Crains Detroit, Appointments News

Awards & Honors

2011  Co-recipient (with Prof. Sean Wu) of President’s Research Enhancement Program in Physical Sciences (WSU). This award carries research funds of $100,000 for a study “Tinnitus Diagnosis and Treatment via Innovative Acoustic/Neural Stimulus and Imaging Technologies”.

2010  Nominee of 2011 President’s Award for Excellence in Teaching, WSU.

Other Information

Currently Teaching

  • PSL7660 Advanced Neurophysiology

Courses Taught

  • AUD 6400 Anatomy & Physiology of the Auditory System
  • AUD 7410 Psychoacoustics
     

Grant Support

  • National Institute on Deafness and Other Communication Disorders
  • The Department of Defense
  • Tinnitus Research Consortium
  • American Tinnitus Association
  • Action on Hearing Loss
  • Tinnitus Research Initiative
  • Del Harder Research Foundation
  • National Science Foundation

 

Areas of Interest

Dr. Zhang's current research interests include:

  1) Electrical suppression of tinnitus in animal and human models;
  2) Development of advanced auditory neural implants; and
  3) Mechanisms of noise and blast-induced tinnitus.

He has extensive background in conducting animal research in the areas of auditory electrophysiology, tinnitus (noise and blast-induced) and auditory prosthesis. His expertise spans broad technical domains with specific interests and direct experience in tinnitus and electrical suppression of tinnitus, cochlear and auditory brainstem implants, neuroanatomy, auditory electrophysiology, optical imaging, neuropharmacology, behavioral assays of hearing and tinnitus, psychophysics, and magnetic resonance imaging (MRI) including, susceptibility weighted imaging (SWI), diffusion tensor imaging (DTI), MR spectroscopy (MRS), and manganese-enhanced MRI (MEMRI). Recently, his research has expanded to conducting tinnitus research directly in human subjects.

Publications

Journal articles (last five years):

Gao, Yayue; Cao, Shuyang; Qu, Tianshu; Wu, Xihong; Li, Haifeng; Zhang, Jinsheng; Li, Liang. (2014) Voice-Associated Static Face Image Releases Speech from Informational Masking. PsyCh Journal. 3(2)113-120.

Mahmood, G., Mei, Z.G., Hojjat, H., Pace, P., and Zhang, J.S. (2014) Therapeutic Effect of Sildenafil on Blast-Induced Tinnitus and Auditory Impairment. Neurosci. 269:367-382.

Luo, H., Pace, E., Zhang, X. and Zhang, J.S. (2014) Blast Induced Tinnitus and Spontaneous Firing Changes in the Rat Dorsal Cochlear Nucleus. J. Neurosci Res. 92(11)1466-1477.

Hao Luo, Xueguo Zhang, Edward Pace and Jinsheng Zhang (2014) “Blast-Induced Tinnitus and Hearing Loss and Their Related Neural activity Changes in the Rat Inferior Colliculus”. Neurosci Lett. 580:47-51.

Gao Y, Cao S, Qu T, Wu X, Li H, Zhang JS, Li L. (2014) Voice-Associated Static Face Image Releases Speech from Informational Masking, PsyCh Journal. 3:113-120.

Zhang JS, Liu B, Luo H, Kim E, Tu H, Pace E, Bao SW, and Xu Y. (2015) Targeted Optogenetic Corticofugal Modulation to Suppress Tinnitus. Bio-Medical Materials Engineering- ICBE2288-THC. 

Xin-Xing Wang, Yan Jin, Hui Sun, Chunlei Ma, Jinsheng Zhang, Ming Wang, Lin Chen Rebound depolarization in neurons of the rat's (2015) medial geniculate body: I. Dependence on the resting membrane potential. Hearing Research.

Xin-Xing Wang, Yan Jin, Bin Luo, Jing-Wu Sun, Jinsheng Zhang, Ming Wang, Lin Chen (2015) Sodium salicylate potentiates the GABAb-GIRK pathway to suppress rebound depolarization in neurons of the rat's medial geniculate body. Hearing Research. 332: 104-112.

Eric Kim, Hongen Tu, Hao Luo, Bin Liu, Shaowen Bao, Jinsheng Zhang and Yong Xu (2015) 3D silicon neural probe with integrated optical fibers for optogenetic modulation. Lab on a Chip, Royal Society of Chemistry, DOI: 10.1039/C4LC01472C.

Zhang JS, Pace E. (2016) Drug Treatments for Tinnitus: What’s New? North American Brain Injury Association (NABIS) - Brain Injury Professional.

Wang XX, Jin Y, Luo B, Sun JW, Zhang J, Wang M, and Chen L. (2016a). Sodium salicylate potentiates the GABAB-GIRK pathway to suppress rebound depolarization in neurons of the rat's medial geniculate body. Hear Res 332, 104-112.

Wang XX, Jin Y, Sun H, Ma C, Zhang J, Wang M, and Chen L. (2016b). Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro. Neurosci Bull 32, 16-26.

Zhang JS, Luo H, Pace E, Liu B. (2016) Psychophysical and Neural Correlates of Noised-Induced Tinnitus in Animals: Intra- and Inter-Auditory and Non-Auditory Brain Structure Studies. Hearing Res. 334:7-19.

Pace E, Luo H, Bobian M, Panekkad A, Zhang X, Zhang H, Zhang JS. (2016). A Conditioned Behavioral Paradigm for Assessing Onset and Lasting Tinnitus in Rats. PLoS One. e0166346. doi: 10.1371/journal.pone.0166346. PubMed PMID: 27835697.

Luo H, Pace E, Zhang, J.S. (2016) Blast-induced tinnitus and hyperactivity in the auditory cortex of rats. Neuroscience 340, 515-520.

Liu B, Kim E, Meggo A, Gandhi S, Luo H, Kallakuri S, Xu Y, Zhang J. (2017). Enhanced biocompatibility of neural probes by integrating microstructures and delivering anti-inflammatory agents via microfluidic channels. J Neural Eng, 14(2), 026008. doi:10.1088/1741-2552/aa52dc.

Ahsan SF, Luo H, Zhang J, Kim E, Xu Y. An Animal Model of Deep Brain Stimulation (DBS) for Treating Tinnitus: A proof of concept study.  Laryngoscope. 2018 May;128(5):1213-1222. doi: 10.1002/lary.26876. Epub 2017 Sep 19. PMID: 28925013

Ouyang J, Pace E, Lepczyk L, Kaufman M, Zhang J, Perrine SA, Zhang J. Blast-Induced Tinnitus and Elevated Central Auditory and Limbic Activity in Rats: A Manganese-Enhanced MRI and Behavioral Study.  Sci Rep. 2017 Jul 7;7(1):4852. doi: 10.1038/s41598-017-04941-w. PMID: 28687812

Ahsan, S. F., Luo, H., Zhang, J., Kim, E. & Xu, Y. An animal model of deep brain stimulation for treating tinnitus: A proof of concept study. Laryngoscope 128, 1213-1222, doi:10.1002/lary.26876 (2018).

Zhao ZG, Kim E, Luo H, Zhang JS, Xu Y (2018) Flexible deep brain neural probes based on a parylene tube structure. J Micromech Microeng. 2018;28(1). doi: ARTN 015012 10.1088/1361-6439/aa9d61. PubMed PMID: WOS:000417990400002.

Kallakuri S, Pace E, Lu H, Luo H, Cavanaugh J, Zhang J (2018) Time course of blast-induced injury in the rat auditory cortex. PLoS One. 2018;13(2):e0193389. doi: 10.1371/journal.pone.0193389. PubMed PMID: 29489862.

Zhao, Han; Wang, Li; Chen, Liang; Huang, Yi-Na; Zhang, Jinsheng; Sun, Wei; Salvi, Richard; Wang, Ming; Chen, Lin (2018) Temporary conductive hearing loss in early life impairs spatial memory of rats in adulthood. Brain and Behavior. Brain and Behavior, DOI: 10.1002/brb3.1004

Masri S, Zhang LS, Luo H, Pace E, Zhang J, Bao S (2018), Blast Exposure Disrupts the Tonotopic Frequency Map in the Primary Auditory Cortex. Neuroscience 379:428-434.

Weihua Wang, Wang W, Zinsmaier AK, Firestone E, Lin R, Yatskievych TA, Yang S, Zhang J, Bao S (2018), Blocking Tumor Necrosis Factor-Alpha Expression Prevents Blast-Induced Excitatory/Inhibitory Synaptic Imbalance and Parvalbumin-Positive Interneuron Loss in the Hippocampus. J Neurotrauma 35:2306-2316.

Syed F. Ahsan, Anika Miggo, Hossein Mahboubi, Hao Luo, Jinsheng Zhang (2018) Effects of Transtympanic Gadolineum on Hearing in Rats. Larynogscope.

Geng R, Furness DN, Muraleedharan CK, Zhang J, Dabdoub A, Lin V, Xu S. The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells. Scientific reports. 2018. p. 18022.

Weihua Wang, Li S. Zhang, Alexander K. Zinsmaier, Genevieve Patterson, Emily Jean Leptich, Savannah L. Shoemaker, Tatiana A. Yatskievych, Robert Gibboni, Edward Pacec, Hao Luo, Jinsheng Zhang, Sungchil Yang, Shaowen Bao (2019) Neuroinflammation Mediates Noise-Induced Synaptic Imbalance and Tinnitus in Rodent Models. PLoS Biology, 17, e3000307.

 

Book chapters (last five years):

Zhang, J.S., Hao Luo and Edward Pace (2017) “Animal Model of Tinnitus”, Chapter 4, In: Tinnitus – Diagnosis/Treatment, Shulman et al (Ed.), Thieme Publishers, New York.

Zhang, J.S. and Shulman, A. (2017) “Inflammation and Tinnitus”, Chapter 5, In: Tinnitus – Diagnosis/Treatment, Shulman et al (Ed.), Thieme Publishers, New York.

Seidman, M.D. and Zhang, J.S. (2017) “Electrical Stimulation of the Brain and Neuromodulation”, Chapter 60, In: Tinnitus – Diagnosis/Treatment, Shulman et al (Ed.), Thieme Publishers, New York.
 

Research

Areas of Research Interest:

  • Electrical suppression of tinnitus in animal and human models
  • Development of advanced auditory neural implants
  • Mechanisms of noise and blast-induced tinnitus

Specifically:

  • Understand the mechanisms that underlie tinnitus and electrical suppression of tinnitus using an animal model, combined with neural implantation, electrical stimulation, behavioral assay and multichannel electrophysiology and confocal microscopy.
  • Develop innovative neural implants to reverse/suppress tinnitus in both animal and human subjects.
  • Understand the mechanisms underlying electrical stimulation-induced hearing, neural activation along the auditory pathways following electrical stimulation of the cochlear nucleus.
  • Improve the auditory brainstem implants through developing advanced implantable electrodes, targeted implantation and optimized stimulation strategies.
  • Investigate noise and blast-induced tinnitus, hearing loss and other non-auditory neurological disorders using behavioral assays and MRI imaging technology.

Overview of Laboratory of Tinnitus and  Auditory Neuroscience Research

Collaborators

Mentoring Activity

Student Awards

Lab Gallery


 

Joint Appointments

Department of Communication Sciences & Disorders at Wayne State University College of Liberal Arts & Sciences

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