George Yoo, M.D.

George Yoo, M.D.


313-832-4537 (fax)

George Yoo, M.D.

Narrative Bio

Dr. George Yoo is a head and neck surgical oncologist and a Professor in the departments of Otolaryngology-Head and Neck Surgery at Wayne State University (WSU) and the Karmanos Cancer Center (KCC).  Dr. Yoo is an expert in the surgical management of head and neck (mouth and throat) cancers along with melanoma, thyroid, parotid and sinus tumors.  Dr. Yoo has been selected as "The Best Doctors in America", "HOUR Detroit Magazine", "Top Doctors", and "Who's Who in America". 

At KCC, Dr. Yoo is the Chief Medical Officer and Director of Clinical Affairs.  He serves as the Chair of the Surgery Committee in the Southwest Oncology Group (SWOG).

Dr. Yoo completed his residency in Otolaryngology-Head and Neck Surgery at Johns Hopkins Hospital (JHH) in 1995 and then completed a fellowship at JHH in 1996.  He is a diplomat of the American Board of Otolaryngology-Head and Neck Surgery.  Dr. Yoo's current research interests include gene therapy and surgical adjuvant therapy for head and neck cancer.  He has published over 70 articles and 6 chapters on head and neck cancer. 

Position Title

Research Educator track, full time
Chief Medical Officer, Karmanos Cancer Institute
Physician in Chief, Karmanos Cancer Institute
Director of Clinical Affairs, Karmanos Cancer Institute

Office Address

Wayne State University - Medicine
4201 St. Antoine
Detroit, MI 48201

Karmanos Cancer Center 
4100 John R 
Mailcode: HW02EA 
Detroit, MI  48201

Additional clinical office:
Weisberg Clinic
31995 Northwestern Highway
Farmington Hills, MI  48334


  • HOUR Detroit Magazine - Top Doctors: 2005, 2006, 2008, 2010-2018 (Top Doctors are selected using a survey of medical professionals in southeast Michigan.  Six thousand doctors and nurses in metro Detroit were asked "To whom would you refer a loved one for medical care?".  The annual Top Docs survey includes doctors in 66 specialties. 
  • The Best Doctors in America, 2005-2015  (Best Doctors is national organization that chooses awardees by peer-review-based evaluation by surveying physician.)
  • Newsweek Top Cancer Doctors: 2015
  • Castle Connolly Medical Ltd., America’s Top Doctor: 2012-2014, 2017
    Castle Connolly Medical Ltd., America's Top Doctors for Cancer: 2013-2014, 2016
  • Detroit Super Doctors, 2014

Other Information

Grants (last 5 years)

NCI NIH, 5P50 CA 097248-7, 10%  "SPORE and Head and Neck Cancer; The Molecular Basis of Head and Neck Cancer Biology Treatment and Prevention" Co-Investigator, (PI: Gregory Wolf, MD) 1/1/09-12/31/15
Provide scientific direction and coordination for the implementation and quality control of the study. 

NCI-Southwest Oncology Group, cooperative group grant, 10%, Co-Investigator.  1/01/06 - 2/29/19
Provide surgical leadership of the administrative and scientific functions of SWOG.

NCI-Southwest Oncology Group, 10%, Southwest Oncology Group, Wayne State University institutional grant, Co-Investigator.  1/01/04 - 12/31/14
Provide leadership of the administrative and scientific functions of SWOG.


Application No: 60/436,754  Overexpression of exogenous p53 on HPV-immortalized and carcinogen transformed keratinocytes. Inventor: George H Yoo 

Areas of Interest

Head and Neck Surgical Oncology 
Free flap reconstruction



Selected original observations in refereed journals (last 5 years)

Laura S. Rozek, Sharma Virani, Emily L. Bellile, Jeremy M.G. Taylor, Maureen A. Sartor, Katie R. Zarins, A. Virani, C. Cote, Francis P. Worden, Mark E. Prince Mark, Scott A. McLean, Sonya A. Duffy, George H. Yoo, Nabil F. Saba, Dong M. Shin, Omer Kucuk & Gregory T. Wolf: Soy Isoflavone Supplementation Increases Long Interspersed Nucleotide Element-1 (LINE-1) Methylation in Head and Neck Squamous Cell Carcinoma, Nutrition and Cancer, 2019. DOI:10.1080/01635581.2019.1577981

Blasco MA*, Svider PF*, Tenbrunsel T, Vellaichamy G, Yoo GH, Fribley A, Raza SN. Recent Trends in Oropharyngeal Cancer Funding and Public Interest. The Laryngoscope. April 2017. DOI: 10.1002/lary.26471

Mikaso Nagasaka, Mark Zaki, Harold Kim, S. Naweed Raza, George Yoo, Ho-sheng Lin, Ammar Sukari. PD1/PD-L1 inhibition as a potential radiosensitizer in head and neck squamous cell carcinoma: a case report. Journal for Immuno Therapy of Cancer. November 15, 2016

Svider PF, Blasco M, Raza SN, Shkoukani M, Sukari A, Yoo G, Folbe AJ, Lin HS, Fribley A. Head and Neck Cancer: Underfunded and Understudied? Otolaryngol Head Neck Surg. 2017 Jan;156(1):10-13. doi: 10.1177/0194599816674672. Epub 2016 Nov 14.

Shamit Chopra, Dev Kamdar, David Cohen, Lance Heilbrun, Daryn Smith, Harold Kim, Ho-sheng Lin, John Jacobs, George Yoo. Outcomes of nonsurgical management of locally advanced carcinomas of the sinonasal cavity. Laryngoscope 2017 Apr;127(4):855-861. doi: 10.1002/lary.26228. Epub 2016 Nov 15

Zeenat Yousuf Bhat, Pravit Cadnapaphornchai, Kevin Ginsburg, Milani Sivagnanam, Shamit Chopra, Corey K. Treadway, Ho-Sheng Lin, George Yoo, Ammar Sukari, Mona D. Doshi. Understanding the risk factors and long-term consequences of Cisplatin associated acute kidney injury: An observational cohort study. PLOS ONE , DOI: 10.1371/journal.pone.0142225, November 10, 2015

Sidhu A, Miller JR, Tripathi A, Garshott DM, Brownell AL, Chiego DJ, Arevang C, Zeng Q, Jackson LC, Bechler SA, Callaghan MU, Yoo GH, Sethi S, Lin HS, Callaghan JH, Tamayo-Castillo G, Sherman DH, Kaufman RJ, Fribley AM. Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-DependentApoptosis. ACS Med Chem Lett. 2015 Sep 8;6(11):1122-7. doi: 10.1021/acsmedchemlett.5b00133. eCollection 2015 Nov 12.

Lin HS, Rowley JA, Folbe AJ.,Yoo GH, Badr MS, Chen W: Transoral Robotic Surgery for Treatment of Obstructive Sleep Apnea: Factors Predicting Surgical Response. Laryngoscope. 2014 Oc24. Doi: 10.1002/lary.24970. [Epub ahead of print] PMID: 25346038. 

Y Xi, D M Garshott, A L Brownell, G H Yoo, H S Lin, T L Freeburg, N G Yoo, R J Kaufman, M U Callaghan, A M Fribley. Cantharidins Induce ER Stress and a Terminal Unfolded Protein Response in OSCC. J Dent Res published online 25 November 2014; DOI 10.1177/0022034514559376.

Books/Book Chapters (last 5 years)

Michael Z Chen, Robert H Mathog, Andrew M Fribley, George H Yoo. Oral Cancer: Location, staging, surgical management and outcomes. In Targeting Oral Cancer. - Springer, May 2016

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