School of Medicine

Wayne State University School of Medicine

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Jinsheng Zhang, Ph.D., Ph.D.
Professor
Research Educator track, full time
Associate Chair for Research
Director - Laboratory of Tinnitus and Auditory Neuroscience Research
Wayne State University - School of Medicine
Otolaryngology
Lande, 254
550 E. Canfield
Detroit, MI 48201
(313) 577-0066 (Office)
(313) 577-0190 (Lab)
Biography

Professor Zhang received a Ph.D. in auditory neurophysiology at Univ. of Fribourg in Switzerland in 1997. He is a tenured full Professor in the Department of Otolaryngology, School of Medicine and the Department of Communication Sciences & Disorders, College of Liberal Arts and Sciences, Wayne State University.  He is the Vice Chair for Research and Research Director of the Department of Otolaryngology at Wayne State Univ.  His tinnitus research career started in 1997, with interests encompassing neural mechanisms underlying noise-and blast-induced tinnitus and mild traumatic brain injury and their neuromodulation (acoustic, electrical, pharmacological and optogenetic).  During Ph.D. training with Professor Eric Rouiller (1994-1997), he characterized neural activation along the rat auditory pathways following cochlear electrical stimulation. During postdoctoral training with Professor James Kaltenbach (1997-2000), he studied noise-induced hyperactivity in the dorsal cochlear nucleus (DCN) and other centers and their relationship to tinnitus. Since then, he has developed multi-structural recordings from both auditory and non-auditory centers for investigation of how neural network within and across different centers contributes to tinnitus.  Recently he demonstrated that auditory cortex electrical stimulation suppresses tinnitus and that DCN electrical stimulation not only suppresses tinnitus but also induces hearing in a rat model.  He is now investigating how cochlear stimulation suppresses tinnitus.  He aims to understand how bottom-up and peripheral modulation suppresses tinnitus compared to top-down and central modulation.  His eventual goal is to develop effective drug and device treatments for tinnitus.

Over the years, Professor Zhang has served as principal investigator or co-investigator on National Institute of Health-, Department of Defense- and National Science Foundation-, university-, and foundation-funded grants.  He has over 70 publications, holds 3 patents, and has trained over 40 researchers, students and other trainees.  He was invited to speak at several international tinnitus conferences including Asian-Pacific International Tinnitus Symposium, International Tinnitus Seminar, Tinnitus Research Initiative International Meeting, International Association of Physician in Audiology, and DOD International Tinnitus Conference.  Professor Zhang serves as a reviewer for a number of scientific journals, as well as federal, international and private funding agencies.  He also serves as an Associate Editor of JMIHI, Journal of Medical Imaging and Health Informatics, guest associate editor of the Journal of American Audiology, board officer of the Lions Hearing Center of Michigan, Scientific advisory committee of the XIth International Tinnitus Seminars in Berlin and the 9th TRI International Tinnitus Conference.  He is recently serving as the Chair of the Scientific Research Advisory Committee of the American Tinnitus Association.  He and Prof. Arnaud Norena successfully organized a special issue on tinnitus, with 21 contributions from experts around the world.  This issue appears in the journal Frontiers in Neurology, Otology Section-2015 (http://journal.frontiersin.org/researchtopic/tinnitus-an-attempt-to-confront-the-diverse-models-2633).

In teaching, Dr. Zhang offers two courses each year, which are Anatomy and Physiology of the Auditory System (AUD 6400) & Psychoacoustics (AUD 7410) in the Department of Communication Sciences and Disorders. He also teaches basic science courses for residents and fellows in the Department of Otolaryngology. He participates in teaching Advanced Neurophysiology (PSL 7660) offered to Ph.D. students in School of Medicine.

Education
1985-1988   M.S. in Physiology, Hebei Normal University, China
1994-1997   Ph.D. in Auditory Neurophysiology, University of Fribourg, Switzerland
1998-2001   
M.S. courses in Electronics and Computer Control System, Wayne State University
1997-2000  
Postdoctoral training, Department of Otolaryngology, Wayne State University

Faculty Appointments
2012-present  Professor, Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine.
2006-2012
       Associate Professor, Department of Communication Sciences and Disorders, College of Liberal Arts & Sciences, Wayne State University.
2005-2012       Associate Professor, Department of Otolaryngology- Head and Neck Surgery, Wayne State University School of Medicine.
2000-2005       Assistant Professor, Department of Otolaryngology- Head and Neck Surgery, Wayne State University School of Medicine.
1990-1993       
Instructor, Department of Biology, Hebei Normal University, Shijiazhuang, China.

Other Professional Appointments
2007-Present  Associate Faculty in Department of Physiology, Wayne State University School of Medicine.
1997-2000       
Research Associate, Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine.
1994-1997     
  Research Assistant, Institute of Physiology, University of Fribourg, Switzerland.
1988-1990       
Teaching Assistant, Biology Department, Hebei Normal University, China.

Service
2015-2017       Board of Directors, The American Tinnitus Association (ATA).
2015-2017       Chair, Scientific Advisory Committee, The American Tinnitus Association (ATA).
2014-2015       Scientific Advisory Committee, The 9th TRI International Tinnitus Conference – Tinnitus from Cochlea to Brain and Back.
2014-2015       Editor, Special Issue in Frontiers in Neurology - Tinnitus: An Attempt to Confront the Diverse Models.
2013-2016       ARO External Relations Committee
2013                TRI Panel Chair. The 7th International TRI Conference on tinnitus.
2012-present  Associate Chair for Research, Dept Otolaryngology, Wayne State University School of Medicine
2012-2014       ITS Scientific Committee, XI International Tinnitus Seminar, Berlin, Germany
2010-2014       ATA Scientific Advisory Committee, American Tinnitus Association
2007-present  Research Director, Department of Otolaryngology, Wayne State University School of Medicine
2006-present  Ex-Officio Board Member, Lions Hearing Center of Michigan

Editorial Board:
2008                Guest Associate Editor, Journal of American Audiology
2014–2015      Editor, Special Issue on Tinnitus, Frontiers in Neurology, Otology Section
2014–2016      Associate Editor, JMIHI, Journal of Medical Imaging and Health Informatics

Journal Reviewer:
  EBR - Experimental Brain Research
  MCBI - Molecular and Cellular Biochemistry
  Audiology and Neuro-Otology
  Journal of Neuroscience (Society for Neuroscience)
  Hearing Research
  Journal of Orofacial Pain
  JNR - Journal of Neuroscience Research.
  Journal of American Audiology
  Journal of Controlled Release
  Growth Hormones & IGF Research
  Ear and Hearing
  Neuroscience
  Physiology & Behavior
  Journal of Neuroinflammation
  Physiology & Behavior
  Neuroscience & Biobehavioral Reviews
  Brain Research
  Journal of American Academy of Audiology
  PLOS ONE
  JARO, Journal of Associate for Research in Otolaryngology
  Journal of Neurophysiology
  Journal of Neuroscience Methods
  Journal of Neural Engineering
  Cellular Physiology and Biochemistry

Professional Memberships:
  Association for Research in Otolaryngology (ARO)
  Member, American Tinnitus Association (ATA)
  Society for Neuroscience (SFN) 

Awards & Honors

2011  Co-recipient (with Prof. Sean Wu) of President’s Research Enhancement Program in Physical Sciences (WSU). This award carries research funds of $100,000 for a study “Tinnitus Diagnosis and Treatment via Innovative Acoustic/Neural Stimulus and Imaging Technologies”.

2010  Nominee of 2011 President’s Award for Excellence in Teaching, WSU.

Areas of Interest

Dr. Zhang's current research interests include:
  1) Electrical suppression of tinnitus in animal and human models;
  2) Development of advanced auditory neural implants; and
  3) Mechanisms of noise and blast-induced tinnitus.
He has extensive background in conducting animal research in the areas of auditory electrophysiology, tinnitus (noise and blast-induced) and auditory prosthesis. His expertise spans broad technical domains with specific interests and direct experience in tinnitus and electrical suppression of tinnitus, cochlear and auditory brainstem implants, neuroanatomy, auditory electrophysiology, optical imaging, neuropharmacology, behavioral assays of hearing and tinnitus, psychophysics, and magnetic resonance imaging (MRI) including, susceptibility weighted imaging (SWI), diffusion tensor imaging (DTI), MR spectroscopy (MRS), and manganese-enhanced MRI (MEMRI). Recently, his research has expanded to conducting tinnitus research directly in human subjects.

Joint Appointments
Department of Communication Sciences & Disorders at Wayne State University College of Liberal Arts & Sciences
Other Information


Course Taught 

PSL7660 Advanced Neurophysiology



Grant Support
 
National Institute on Deafness and Other Communication Disorders 
The Department of Defense 
Tinnitus Research Consortium 
American Tinnitus Association 
NIDCD/NIH 
Del Harder Research Foundation 
Action on Hearing Loss 
Tinnitus Research Initiative 
National Science Foundation
Research

Areas of Research Interest:

  • Electrical suppression of tinnitus in animal and human models
  • Development of advanced auditory neural implants
  • Mechanisms of noise and blast-induced tinnitus

Specifically:

  • Understand the mechanisms that underlie tinnitus and electrical suppression of tinnitus using an animal model, combined with neural implantation, electrical stimulation, behavioral assay and multichannel electrophysiology and confocal microscopy.
  • Develop innovative neural implants to reverse/suppress tinnitus in both animal and human subjects.
  • Understand the mechanisms underlying electrical stimulation-induced hearing, neural activation along the auditory pathways following electrical stimulation of the cochlear nucleus.
  • Improve the auditory brainstem implants through developing advanced implantable electrodes, targeted implantation and optimized stimulation strategies.
  • Investigate noise and blast-induced tinnitus, hearing loss and other non-auditory neurological disorders using behavioral assays and MRI imaging technology.

Overview of Laboratory of Tinnitus and  Auditory Neuroscience Research

Lab Gallery

Collaborators

Mentoring Activity

Student Awards


 

Selected Publications

Journal articles (last five years):

1. Zhang, J.S., Guan, Z.G., Zhang, X.G., Beydoun, H., Zhang, J., Seidman, M., Elisevich, K., Bowyer, S., Jiang, Q. and J Moran (2010) Cortical modulation of tinnitus and its neural correlates. N.Z.Med.J, 123, 77-88.

2. Talukder, M.I., P Siy, P., Auner, G.W. and Zhang, J.S. (2009) The methodology of probe design with the better resolution and less resistive donut probe to achieve the best performance. J. Bionic Eng. 6:239-245.

3. Zhang, J.S. Zhang, X.G. (2010) Electrical stimulation of the dorsal cochlear nucleus induces hearing in rats. Brain Res. 1311:37-50.

4. Zhang, J.S., Zhang, Y.P. and Zhang, X.G. (2011) Auditory cortex electrical stimulation suppresses tinnitus in rats. J Assoc Res Otolaryngol. 12(2):185-201.

5. Zhu, Na, Wu, Sean. and Zhang, Jinsheng. (2011) Development of three-dimensional time reversal algorithm to locate tinnitus-related hyperactive neurons. The Journal of the Acoustical Society of America 10/2011; 130(4):2453. 

6. Ereifej E, Khan S, Newaz G, Zhang J.S., Auner G, VandeVord P. (2011) Characterization of astrocyte reactivity and gene expression on biomaterials for neural electrodes. J. Biomed Mater Res., 99(1):141-150.

7. John, J., Li, Y.F., Zhang, J.S., Loeb, J. and Xu, Y. (2011) Microfabrication of 3D neural probes with combined electrical and chemical interfaces. J Micromech. Micoeng., 21:105011 (11pp).

8. Mao, J., Pace, E., Pierozynski, P., Bobak, L., Kou, Z. F., VandeVord, P., Shen, Y.M., Haacke, M., Zhang, X.G., Zhang, J.S. (2012) Blast-induced tinnitus and hearing loss in rats: Behavioral and imaging assays. J. Neurotrauma, 29:430-444.

9. Luo, H., Zhang, X.G. Nation, J. Pace, E., Lepczyk, L. and Zhang, J.S. (2012) Tinnitus Suppression by Electrical Stimulation of the Rat Dorsal Cochlear Nucleus. Neurosci Lett. 26;522(1):16-20

10. Ereifei, ES, Khan S, Newaz G, Zhang, J.S., Auner GW and VandeVord PJ (2013) Comparative Assessment of Iridium Oxide and Platinum Alloy Wires using an in vitro Glial Scar Assay. Biomedical Microdevices. 15(6):917-924.

11. Church MW, Zhang, J.S., Langford MM, and Perring SA (2013) “Ecstasy” Enhances Noise-Induced Hearing Loss. Hearing Research. 302C:96-106.

12. Pace, E. and Zhang, J.S. (2013) Noise-Induced Tinnitus Using Individualized Gap Detection Analysis and Its Relationship with Hyperacusis, Anxiety, and Spatial Cognition. PloS ONE PloS ONE 8(9): e75011.

13. Kim, E.G., John, J.K., Tu, H., Zheng, Q., Loeb, J., and Zhang, J.S., and Xu, Y. (2013) A hybrid silicon-parylene neural probe with locally flexible regions.

14. Gao, Yayue; Cao, Shuyang; Qu, Tianshu; Wu, Xihong; Li, Haifeng; Zhang, Jinsheng; Li, Liang. (2014) Voice-Associated Static Face Image Releases Speech from Informational Masking. PsyCh Journal. 3(2)113-120.

15. Mahmood, G., Mei, Z.G., Hojjat, H., Pace, P., and Zhang, J.S. (2014) Therapeutic Effect of Sildenafil on Blast-Induced Tinnitus and Auditory Impairment. Neurosci. 269:367-382.

16. Luo, H., Pace, E., Zhang, X. and Zhang, J.S. (2014) Blast Induced Tinnitus and Spontaneous Firing Changes in the Rat Dorsal Cochlear Nucleus. J. Neurosci Res. 92(11)1466-1477.

17. Hao Luo, Xueguo Zhang, Edward Pace and Jinsheng Zhang (2014) “Blast-Induced Tinnitus and Hearing Loss and Their Related Neural activity Changes in the Rat Inferior Colliculus”. Neurosci Lett. 580:47-51.

18. Gao, Y., Cao, S., Qu, T., Wu, X., Li, H., Zhang, J.S., Li, L. (2014) Voice-Associated Static Face Image Releases Speech from Informational Masking, PsyCh Journal. 3:113-120.

19. Zhang, J.S., Liu, B., Luo, H., Kim, E., Tu, Hongen, Pace, E, Bao, S.W., and Xu, Y. (2015) Targeted Optogenetic Corticofugal Modulation to Suppress Tinnitus. Bio-Medical Materials Engineering- ICBE2288-THC. 

20. Xin-Xing Wang, Yan Jin, Hui Sun, Chunlei Ma, Jinsheng Zhang, Ming Wang, Lin Chen Rebound depolarization in neurons of the rat's (2015) medial geniculate body: I. Dependence on the resting membrane potential. Hearing Research.

21. Xin-Xing Wang, Yan Jin, Bin Luo, Jing-Wu Sun, Jinsheng Zhang, Ming Wang, Lin Chen (2015) Rebound depolarization in neurons of the 1 rat's medial geniculate body: II. Suppression by sodium salicylate through the GABAb-GIRK pathway. Hearing Research.

22. Eric Kim, Hongen Tu, Hao Luo, Bin Liu, Shaowen Bao, Jinsheng Zhang and Yong Xu (2015) 3D silicon neural probe with integrated optical fibers for optogenetic modulation. Lab on a Chip, Royal Society of Chemistry, DOI: 10.1039/C4LC01472C. 


Book chapters (last five years):
 
1. Zhang, J.S., Hao Luo and Edward Pace (2015) “Animal Model of Tinnitus”, Chapter 4, In: Tinnitus – Diagnosis/Treatment, Shulman et al (Ed.), Thieme Publishers, New York.
 
2. Zhang, J.S. and Shulman, A. (2015) “Inflammation and Tinnitus”, Chapter 5, In: Tinnitus – Diagnosis/Treatment, Shulman et al (Ed.), Thieme Publishers, New York.
 
3. Seidman, M.D. and Zhang, J.S. (2015) “Electrical Stimulation of the Brain and Neuromodulation”, Chapter 60, In: Tinnitus – Diagnosis/Treatment, Shulman et al (Ed.), Thieme Publishers, New York.