School of Medicine

Wayne State University School of Medicine

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Ho-Sheng Lin, M.D.
Professor and Chairman

UHC 5E
4201 St. Antoine
Detroit, MI  48201

313-745-1730
Biography

Ho-Sheng Lin, MD, FACS is a Professor and the Chairman of the Department of Otolaryngology - Head and Neck Surgery at Wayne State University (WSU) School of Medicine.  He received his MD from Yale University School of Medicine and then went on to complete an Otolaryngology residency at The New York Hospital-Cornell Medical Center and New York University Medical Center. After his residency, Dr. Lin completed fellowship training in Head and Neck Surgical Oncology at Stanford University.  He joined the Department of Otolaryngology at WSU in 2002. 

 

Dr. Lin's clinical interests include surgical treatment of cancer and disease involving the mouth, throat, neck, thyroid, parathyroid, and salivary glands as well as surgical treatment of obstructive sleep apnea (OSA) and snoring.  He has special interest in the use of new and minimally invasive technology in head and neck surgery.  He has used Harmonic technology for minimally invasive thyroid surgery.  He is the first surgeon in the state of Michigan to use the robotic technology (da Vinci robot) to perform surgery on the larynx (voice box) and pharynx (throat) for treatment of cancer and sleep apnea.  He is also the first Otolaryngologist in Michigan to perform a robotic-assisted thyroidectomy (thyroid surgery without a neck incision).  Dr. Lin is also a Principal Investigator in the use of novel and minimally invasive surgical approaches for treatment of OSA.  He has been involved in several industry sponsored clinical trials such as the Pillar implant (Restore Medical) and hypoglossal nerve implant (Inspire Medical) to assess the effectiveness of these new surgical approaches. 

 

Dr. Lin's basic science research, funded by the Department of Veterans Affairs and National Cancer Institute, focuses on the development of a blood test for early detection of head and neck cancer in high risk patients.  In a paper published in Cancer Epidemiology, Biomarkers, and Preventions, he showed the use of high throughput protein microarray technology for identification of promising cancer biomarkers.  A diagnostic strategy, based on analysis of the interactions of these biomarkers with patients' sera, was capable of detecting cancer with 85% accuracy.  He has been invited to give talks on this topic in national and international meetings including the NIH's Early Detection Research Network meetings in Washington DC and Seattle.  He is currently working in collaboration with investigators from Johns Hopkins and University of Pittsburgh to further validate this diagnostic strategy.

 

In addition to his involvement in the residency program, Dr. Lin is also involved in both head and neck as well as sleep fellowship programs at WSU.  Dr. Lin has published extensively with over 60 publications in peer reviewed journals.  He has served on the editorial board of several journals including Laryngoscope, World Journal of Clinical Oncology, Journal of Otology & Rhinology, Otolaryngology-Head and Neck Surgery, Journal of Tumor, and Case Reports in Otolaryngology.  He also served as an ad hoc reviewer for many other journals including Cancer Biomarkers, Head and Neck, Archives of Otolaryngology-Head and Neck Surgery, World Journal of Surgical Oncology, and Journal of Clinical Oncology. 

 

Dr. Lin is a diplomat of the American Board of Otolaryngology-Head and Neck Surgery and is an active member of many professional societies including Southwest Oncology Group (SWOG), American Academy of Otolaryngology-Head and Neck Surgery, Triological Society, American Sleep Association, American College of Surgeons, Society of Robotic Surgery, International Surgical Sleep Society, American Academy of Sleep Medicine, and American Head & Neck Society.  He is active in many committees including the Sleep Disorder Committee and Endocrine Surgery Committee of the American Academy of Otolaryngology and the Section of Sleep Related Breathing Disorders of the American Academy of Sleep Medicine.   He currently has active staff privileges at Karmanos Cancer Institute, Harper University Hospital, Detroit Receiving Hospital, Oakwood Hospital, and John D. Dingell VA Medical Center.  He has been named Best Doctor in America (Best Doctors Inc.) and Top Doctor (Castle Connolly) for several years.  Most recently, he was named the Top Doctor on the US News and World Report.

 

 

Graduate degree:  M.D., Yale University School of Medicine, New Haven, CT, 1994

 

Residency:  General Surgery, New York Hospital-Cornell Medical Center, New

                                        York, NY, 1994-1996

                    Otolaryngology-Head and Neck Surgery, Manhattan Eye, Ear, and Throat

                                        Hospital, New York, NY, 1996-1999

        Otolaryngology-Head and Neck Surgery, New York University, New York,

                            NY, 1999-2000

 

Fellowship:  Advanced Head and Neck Oncologic Surgery, Stanford University Medical

                                        Center, Stanford, CA, 2000-2002

 

Awards & Honors

2014
Star Journal Reviewer, 2014
Otolaryngology-Head and Neck Surgery


2014
Detroit Super Doctors

www.superdoctors.com


2013
Star Journal Reviewer, 2013

Otolaryngology-Head and Neck Surgery

 

2012               

Top Doctors 2012

US News and World Report Top Doctors

http://health.usnews.com/top-doctors

 

9/11/11                       

President's Award for the Clinical Scientific Poster Presentation

Implant Related Outcomes Following Hypoglossal Nerve Implant for OSA

AAO-HNSF 2011 Annual Meeting

 

2009-2013                  

Metro Detroit's Best Doctors in America

Best Doctors Inc. (www.bestdoctors.com)

 

2004-2013                  

Castle Connolly's Top Doctors

 

2003:  Clinical Scholars

National Center for the Promotion of Research in Otolaryngology

American Academy of Otolaryngology-Head and Neck Surgery

Daiichi Corporation

 

2002:  Excellence in Teaching Award

Division of Otolaryngology-Head and Neck Surgery

Stanford University School of Medicine

 

1999: Third place resident research award

New York Academy Resident Research Presentation

 

1998:  Third prize resident research award

Eastern Section of Triological Society

 

1993-94: NIH Cancer One Year Medical Student Research Fellowship

Yale University School of Medicine

 

1989:  Summa Cum Laude

School of Biological Sciences, University of California, Irvine

 

1989: Chinese-American Engineers & Scientists Association of Southern

California academic scholarship

 

1987-89: Phi Beta Kappa

University of California, Irvine

 

1986-88: Chancellor's Club Scholarship

University of California, Irvine
 

Areas of Interest
CLINICAL INTERESTS:
Mouth Cancer
Throat Cancer
Neck Cancer
Thyroid and parathyroid disease and cancer
Parotid and submandibular gland disease and cancer
Obstructive sleep apnea
Snoring
Minimally invasive surgery including TORS (transoral robotic surgery) of pharynx and larynx for cancer and sleep apnea
Robotic assisted thyroidectomy to avoid neck incision

RESEARCH INTERESTS:
Molecular markers for diagnosis and treatment of head and neck Cancer
Other Information

GRANTS   (last 5 years)

09/14-08/15:   Identification of Early Marker for Head and Neck Cancer through Antibody Profiling         

                        Funding Source:   Office of the Vice President for Research, Bridge Funding

                        PI:                         Ho-Sheng Lin

                        Amount:               $35,000

                        Status:                  Active

 

09/13-08/14:    Identification of Early Marker for Head and Neck Cancer through Antibody Profiling

         Funding Source: Office of the Vice President for Research, Bridge Funding

         PI:           Ho-Sheng Lin 

         Role:   PI

         Amount:                 $35,000 

         Status: Closed


 

1/10-5/13:        Proteomic Approach for Early Detection of Head and Neck Cancer

                        Award #:                     I01 BX007080

                        Funding Source:         Biomedical Laboratory Research & Development  
                                                            Service of the VA Office of Research and Development     

                                   (BLR&D) MERIT REVIEW AWARD (PARENT I01)

                        PI:                               Ho-Sheng Lin

                        Role:                           PI

                        Amount:                      $500,000 (3 years-Direct)

                                                            $200,000 (first year)  Direct

                                                            $150,000 (second year)  Direct

                                                            $150,000 (third year)  Direct

                        Status:                          Active

 

10/10-3/11:      Autoantibody Profiling for Serological Detection of Head and Neck Cancer
                        Phase 1 IMAT SBIR
                        RFA/PA:                    PA08-050
                        Application #:            1 R43 CA139806-01
                        Funding Source:        National Cancer Institute
                        PI:                              Nada Khattar and Ho-Sheng Lin
                        Role:                          Co-PI
                        Amount:                    $206,140 (Total Direct-6 months)
                                                          $54,013 (WSU Direct - 6 months)
                        Status:                       Active
                                                          Priority Score = 127


4/09-9/09        Autoantibody Profiling for Serological Detection of Head and Neck Cancer 

                        Phase 1  IMAT SBIR 

                        RFA/PA                           PA08-050

                        Application #:                   1 R43 CA139806-01

                        Funding Source:                National Cancer Institute

                        PI:                                   NadaKhattar and Ho-Sheng Lin

                        Role:                                Co-PI

                        Amount:                          $206,140 (Total Direct- 6 months)

                                                               $  54,013 (WSU Direct- 6 months)

                        Status:                             Closed

 

 

Research

1.  Use of new tools for evaluation of upper airway in patients with obstructive sleep apnea
2.  Use of new surgical techniques in treatment of patients with obstructive sleep apnea
3.  Use of new and minimally invasive technology such as minimally invasive thyroid surgery and robotic technology (Da Vinci robot) in head and neck surgery
4.  Molecular markers for diagnosis and treatment of head and neck Cancer

Clinical Trial Activities 

2012-present:  Phase I/II trial of Cediranib alone or Cediranib and Lenalidomide in iodine 131 refractory differentiated
thyroid cancer
Role: Co-investigator
Status: Current

 

2012-present:  A phase I study of the safety, pharmacokinetics and pharmacodynamics of escalating doses of the 
selective inhibitor of nuclear export (SINE) KPT-330 in patients with advanced or metastatic solid tumor malignancies
Role: Co-investigator
Status: Current

 

2008-2010: Inspire 2 - Human Clinic Trial for Obstructive Sleep Apnea
Funding Source: Inspire Medical Systems, Inc.
Role: co-PI
Status: Closed

 

2008-present: A Pilot Study Assessing the use of Da Vinci Robotic Surgical System in Laryngeal and Pharyngeal Surgeries
National Cancer Institute Clinical Trial Protocol ID: WSU-2008-022
http://www.cancer.gov/clinicaltrials/WSU-2008-022
Funding Source: Karmanos Cancer Institute
PI: Ho-Sheng Lin
Status: Closed

 

2006-present: Prospective, Longitudinal, Multi-Center, Descriptive Registry of Patients Receiving
Therapy other than Surgical Resection Alone for 
Newly Diagnosed Head and Neck Carcinoma
(LORHAN)
Funding Source: ImClone Systems Incorporated
PI: Ho-Sheng Lin
Role: PI at Karmanos Cancer Institute Site
Status: Closed

 

Selected Publications

(last five years)

1.      Dubal DM, Svider PS, Folbe AJ, Lin H, Park RC, Baredes S, Eloy JA. Laryngeal Adenoid Cystic Carcinoma: A Population-Based Perspective. Laryngoscope (in press)

2.      Sukari A, Al-Hajeili M, Salem M, Heilbrun L, Smith D, Yoo GH, Jacobs JR, Lin HS, Kucuk O.  Biweekly Gemcitabine and Paclitaxel in Patients with Relapsed or Metastatic Squamous Cell Carcinoma of Head and Neck.  Avicenna J Med. 2015 Apr-Jun;5(2):36-41. doi: 10.4103/2231-0770.154195.

3.      Xi Y, Garshott D, Free T, Yoo N, Callaghan M, Yoo G, Lin HS, Kaufman R, Fribley A. Cantharidins induce ER stress and a terminal unfolded protein response in OSCC (JDR-14-0354)  J Dent Res. 2015 Feb;94(2):320-9. doi: 10.1177/0022034514559376. Epub 2014 Nov 25.

4.      Dowdall JR, Zak IT, Hamdan MA, Lin HS, Carron MA. (2014) Neurofibromatosis Type-2 Presenting as a Giant Neck Mass and Hearing Loss.  J Otol Rhinol 3:2. doi:10.4172/2324-8785.1000148

5.      Lin HS, Rowley JA, Folbe A, Yoo GH, Badr MS, Chen W. Transoral Robotic Surgery for Treatment of Obstructive Sleep Apnea: Factors Predicting Surgical Response. Laryngoscope. 2015 Apr;125(4):1013-20. doi: 10.1002/lary.24970. Epub 2014 Oct 24.

6.      Boppana NB, Kodiha M, Stochaj U, Lin HS, Haimovitz-Friedman A, Bielawska A, Bielawski J, Divine GW, Boyd JA, Korbelik M, Separovic D. Ceramide synthase inhibitor fumonisin 1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization. Photochem Photobiol Sci. 2014 Nov;13(11):1621-7. doi: 10.1039/c4pp00292j.

7.      Lauren A. Lawrence, Jose L. Jiron, Jr., Ho-Sheng Lin, Adam J. Folbe. Levamisole-Adulterated Cocaine Induced Skin Necrosis of Nose, Ears, and Extremities: Case Report. Allergy Rhinol (Providence). 2014 Jan;5(3):132-6. doi: 10.2500/ar.2014.5.0101.

8.      ElChami M, Shaheen D, Ivers B, Syed Z, Badr MS, Lin HS, Mateika JH. Time of day affects chemoreflex sensitivity and the carbon dioxide reserve during NREM sleep in participants with sleep apnea. J Appl Physiol (1985). 2014 Nov 15;117(10):1149-56. doi: 10.1152/japplphysiol.00681.2014. Epub 2014 Sep 11.

9.      Woodson BT, Gillespie MB, Soose R, Mauer J, deVries N, David Steward, Baskin JZ, Padhya T, Lin HS, Mickelson S, Badr SM, Strohl K, Strollo P, Jr. for the STAR Trial Group*.  Randomized Controlled Trial of Withdrawal Effect for Upper Airway (CNXII) Stimulation on Treatment of Obstructive Sleep Apnea: The STAR Trial.  Otolaryngol Head Neck Surg. 2014 Nov;151(5):880-7. doi: 10.1177/0194599814544445. Epub 2014 Sep 9.

10.  Cohen DS, VandeGriend ZP, Yoo GH, Folbe AJ, Lin HSRisk Stratification Based on Thyroid Cytology: Can We Rely on National Data? Am J Otolaryngol. 2014 May-Jun;35(3):362-5. doi: 10.1016/j.amjoto.2013.12.014. Epub 2014 Jan 2. 

11.  Folbe AJ, Svider PF*, Setzen M, Zuliani G, Lin HS, Eloy JA. Scientific inquiry into rhinosinusitis: who is receiving funding from the national institutes of health?  Laryngoscope. 2014 Jun;124(6):1301-7. doi: 10.1002/lary.24525. Epub 2014 Jan 8.

12.  Lin HS, Talwar HS, Chen W, Voichita C, Smith M, Jalapalan G*, Chatterjee M, Yoo GH, Draghici S, Sethi S, Kim H, Sukari A, Siddiq F, Folbe AJ, Tainsky MA.  Serum Biomarkers of Prognosis in Head and Neck Cancer Patients  Laryngoscope. 2014 Aug;124(8):1819-26. doi: 10.1002/lary.24567. Epub 2014 Jan 29.

13.  Mahmood G*, Patel S*, Lin HSTraumatic Pneumonmediastinum after Emesis Two Years after Laryngeal Fracture Repair.  J Otol Rhinol 2:4. doi:10.4172/2324-8785.1000131  http://www.scitechnol.com/2324-8785/2324-8785-2-131.php?article_id=1386 

14.  Kruper G*, VandeGriend Z*, Lin HS, Zuliani G. Salvage of failed local and regional flaps with porcine urinary bladder extracellular matrix aided tissue regeneration.  Case Reports in Otolaryngol, 2013;2013:917183. doi: 10.1155/2013/917183. Epub 2013 Sep 26. http://www.hindawi.com/crim/otolaryngology/contents/ 

15.  Lin HS, Rowley JA, Badr MS, Folbe A, Yoo GH, Victor L, Mathog R, Chen W. Transoral Robotic Surgery for Treatment of Obstructive Sleep Apnea-Hypopnea Syndrome. Laryngoscope, 2013 Jul;123(7):1811-6. doi: 10.1002/lary.23913. Epub 2013 Apr 2. PMID: 23553290  
http://www.ncbi.nlm.nih.gov.proxy.lib.wayne.edu/pubmed/23553290  

16.  Vanderveken OM, Maurer JT, Hohenhorst W, Hamans E, Lin HS, Vroegop AV, Anders C, de Vries N, Van de Heyning PH. Evaluation of drug-induced sleep endoscopy as a patient selection tool for implanted upper airway stimulation for obstructive sleep apnea. J Clin Sleep Med. 2013 May 15;9(5):433-8. doi: 10.5664/jcsm.2658.  PMID: 23674933

17.  Lin HS. Response to "Robotic thyroidectomy: Seoul is not Varese" by Dr. Dionigi.  Otolaryngol Head Neck Surg. 2013 Jan;148(1):179. doi: 10.1177/0194599812469791. PMID: 23243139

18.  Syed Z, Lin HS, Mateika J. The impact of arousal state, sex, and sleep apnea on the magnitude of progressive augmentation and ventilator long-term facilitation. J Appl Physiol. 2013 Jan 1;114(1):52-65. doi: 10.1152/japplphysiol.00985.2012. Epub 2012 Nov 8. PMID: 23139361

19.  Lin HS, Folbe A, Carron M, Zuliani G, Chen W, Yoo GH, Mathog R. Single-incision trans-axillary robotic thyroidectomy: challenges and limitations in North American Population. Otolaryngol Head Neck Surg. 2012 Dec;147(6): doi: 10.1177/0194599812461610, Epub 2012 Sep 24

20.  Maurer JT, Van de Heyning PH, Baskin JZ, Hohenhorst W, Lin HS, Woodson BT. Operative Technique of Upper Airway Stimulation-An Implantable Treatment of Obstructive Sleep Apnea. Operative Techniques in Otolaryngology (2012) 23, 227-233

21.  Soares D, Folbe AJ, Yoo GH, Badr MS, Rowley JA, Lin HS. Drug Induced Sleep Endoscopy vs. Awake Muller's Maneuver in the Diagnosis of Severe Upper Airway Obstruction.  Otolaryngol Head Neck Surg. 2013 Jan;148(1):151-6. doi: 10.1177/0194599812460505. Epub 2012 Sep 11., PMID: 22968669

22.  Dowdall JR, Opfermann KJ, Kim H, Lin HS. A case of Radiation-induced multifocal laryngeal angiosarcoma presenting as a diagnostic dilemma.  Case Report Otolaryngol. 2012:139310. Epub 2012 Aug13.http://www.hindawi.com/crim/otolaryngology/2012/139310/

23.  Kafri Z, Heilbrun LK, Sukari A, Yoo GH, Jacobs J, Lin HS, Mulrenan H, Smith D, Kucuk O. Phase II study of gemcitabine and docetaxel combination in patients with previously treated recurrent or metastatic Squamous Cell Carcinoma of the Head and Neck. ISRN Oncol. 2012;2012:159568. Epub 2012 May 10. http://www.isrn.com/journals/oncology/2012/159568/

24.  Van de Heyning PH, Badr MS, Baskin JZ, Bornemann MC, De Backer WA, Dotan Y, Hohenhorst W, Knacck L, Lin HS, Maurer JT, Netzer A, Odland RM, Oliven A, Strohl KP, Vanderveken OM, Verbraecken J, Woodson BT. Implanted Upper Airway Stimulation Device for Obstructive Sleep Apnea.  Laryngoscope. 2012 Jul;122(7):1626-33. doi: 10.1002/lary.23301. Epub 2012 May 1.

25.  Paximadis PA, Christensen ME, Dyson G, Kamdar D, Sukari A, Lin HS, Yoo GH, Kim HE. Up-front neck dissection followed by concurrent chemoradiation in regionally advanced head and neck cancer. Head Neck. 2012 Dec;34(12):1798-803. doi: 10.1002/hed.22011. Epub 2012 Feb 6.

26.  Soares D, Sinawe H, Folbe A, Yoo GH, Badr MS, Rowley JA, Lin HS. Lateral Oropharyngeal Wall and Supraglottic Airway Collapse Associated with Failure in Sleep Apnea Surgery. Laryngoscope, 2012 Feb;122(2):473-9. doi: 0.1002/lary.22474. Epub 2012 Jan 17.

27.  Paximadis P, Yoo GH, Lin HS, Jacobs J, Sukari A, Dyson G, Christensen M, Kim H.  Concurrent chemoradiation improves survival in Hypopharyngeal Cancer. Int J Radiat Oncol Biol Phys, 2012 Mar 15;82(4):1515-21. Epub 2011 Jun 12.

28.  Chopra S, Kamdar D, Tulunay Ugur OE, Chen G, Peshek B, Marunick M, Kim H, Lin HS, Jacobs J. Factors predictive of severity of osteoradionecrosis of the mandible. Head Neck, 2011 Nov;33(11):1600-5. doi: 10.1002/hed.21654. Epub 2011 Apr 11.

29.  McCormick M, Folbe AJ, Lin HS, Hooten J, Yoo GH, Krouse JH. Site Involvement as a Predictor of Airway Intervention in Angioedema. Laryngoscope. 2011 Feb;121(2):262-6.

30.  Shkoukani M, Carron M, Tulunay O, Kucuk O, Lin HS. Angiosarcoma of the Scalp with Complete Response to a Biweekly Gemcitabine and Docetaxel (GEMDOC) Chemotherapy Regimen. Ear Nose Throat J. 2011 Jan;90(1):26-29.

31.  Yoo GH, Kafri K, Ensley JF, Leonardo F, Kim H, Folbe A, Won J, Stevens T, Lin HS. XRP6258 Induced Gene Expression Patterns in Head and Neck Cancer Carcinoma. Laryngoscope. 2010 Jun;120(6):1114-9.

32.  Yoo GH, Subramanian G, Ezzat WH, Tulunay OE, Tran V, Lonardo F, Ensley JF, Kim H, Won J, Stevens T, Zumstein LA, Lin HS. Intratumoral delivery of docetaxel enhances anti-tumor activity of Ad-p53 in murine head and neck cancer xenograft model. Am J Otolaryngol. 2010 March - April;31(2):78-83

33.   Narasimhan K, Kucuk O, Lin HS, Helbrun L, Carron M, Venkatramanamoorthy R, Mathog R. Sinonasal Mucosal Melanoma: a Thirteen Year Experience at a Single Institution. Skull Base: An Interdisciplinary Approach. 2009 Jul;19(4):255-62.

Book Authorships and Chapters


Lin H
, Fee WE. Malignant Nasopharyngeal Tumors. Medscape Reference. Updated July 1, 2014. Available at: http://emedicine.medscape.com/article/848163-overview.

Bliznikas D, Lin HS. Chapter 13: The Impact of Surgical Treatment of OSA on Cardiac Risk Factors. Sleep Apnea and Snoring: Surgical and Non-surgical Therapy. Editor: Michael Friedman Elsevier Inc.

Lin, HS, Fee Jr., WE. Chapter on "Nasopharyngeal Carcinoma" eMedicine Online Text (www.emedicine.com)  Revised 8/09