School of Medicine

Wayne State University School of Medicine

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Dennis Drescher, Ph.D.
Professor, Departments of Otolaryngology and Biochemistry
Research Educator track, full time

Wayne State University - Medicine
Otolaryngology
Lande, 259
540 E. Canfield
Detroit, MI 48201

313-577-1650
Biography

Dennis G. Drescher is Professor and Director of Molecular Research in the Department of Otolaryngology-Head and Neck Surgery and Associate member of the Department of Biochemistry-Molecular Biology at Wayne State University.  He obtained B.S., M.M., and Ph.D. (1971, biochemistry) degrees from the University of Wisconsin, Madison, and received postgraduate training at Harvard University and Washington University.  From 1974 to 1978, he served on the research staff at the National Institutes of Health, where he was the first ever to purify a cochlear enzyme, cochlear carbonic anhydrase.

Dr. Drescher joined the Department of Otolaryngology at Wayne State University in 1978 and has pursued research on the molecular biology and biochemistry of hair-cell neurotransmitter systems.  In 1986, he was granted a Javits-Pepper Award from the NIH.  He has served as full-time member of the NIH Hearing Research Study Section IFCN6/AUD, the NIH/NIDCD Communication Disorders Review Committee, numerous NIH ad hoc grant-review committees, and journal editorial boards.  He is author and co-author of over 100 scientific papers, reviews, chapters, and GenBank submissions, over 170 published abstracts, and has trained over 50 postdoctoral fellows/residents and numerous medical students. His avocations include keyboard and music composition.
 
B.S.,   Biochemistry, University of Wisconsin, 1963. 
M.M.,  Biochemistry, University of Wisconsin, 1964.
Ph.D., Biochemistry, University of Wisconsin, 1970.
Areas of Interest
Molecular biology and genetics of otology
Structure and function of the porosome in the hair cell
Post Graduate Training

Sabbatical Fellow (Intergovernmental Personnel Award), Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, 1990-1991.

Senior Staff Fellow (Biochemistry), Laboratory of Neuro-otolaryngology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 1974-1978.

Postdoctoral Research Associate, Central Institute for the Deaf, Washington University, Saint Louis, Missouri, 1971-1974.

Postgraduate, Biochemistry, Harvard University, 1966.
 

Other Information

Grants (last 5 years) 

Drescher, D.G., PI, Drescher, M.J., Co-PI, R01, Identification of Acoustico-Lateralis Transmitters," National Institutes of Health, $1,881,250.  4/09-3/31/15 (2015: 33rd year) $1,881.250   

Drescher, D.G., PI, Drescher, M.J., Co-PI, “Molecular-Functional Comparison of the Dysferlin Membrane Repair Complex with the Otoferlin Synaptic Complex," Jain Foundation, 2014  $121,764

Drescher, D.G., Research Stimulation Award, Office of the Vice President for Research, Wayne State University, 2014  $36,000

Drescher, D.G., Research Stimulation Award, Research and Graduate Programs, Wayne State University School of Medicine, 2014  $36,000

Drescher, D.G., Research Award, Department of Otolaryngology, Wayne State University School of Medicine, 2014  $4,500

Drescher, D.G., Research Stimulation Award, Office of the Vice President for Research, Wayne State University, 2013-2014  $52,000

Drescher, D.G., Research Stimulation Award, Research and Graduate Programs, Wayne State University School of Medicine, 2013  $20,000

Drescher, M.J., PI, Drescher, D.G., Co-PI, R01, "Adenylyl Cyclase Signaling in Ear Sensory Epithelia," National Institutes of Health, 5/1/05-4/30/12  $1,500,000

Ramakrishnan, N.A., PI, Drescher, D.G., Co-PI, “Molecular biology and protein-protein interactions in auditory/vestibular afferent synaptic transmission"  Deafness Research Foundation, 7/1/10-6/30/11  $25,000

Drescher, D.G., PI, "Research Equipment Maintenance Match”, Wayne State University School of Medicine, $2,000. 10/11

Drescher, D.G., PI, Drescher, M.J., Co-PI, R01, ARRA Administrative Supplement, Identification of Acoustico-Lateralis Transmitters," National Institutes of Health, $106,250.  6/09-5/11  

Drescher, D.G., PI, Drescher, M.J., Co-PI, R01, Identification of Acoustico-Lateralis Transmitters," National Institutes of Health, $1,500,000.  7/03-6/09  

Drescher, D.G., PI, Identification of Acoustico-Lateralis Transmitters," Office of the Vice President for Research, Wayne State University, $35,000.  9/08-3/09  

Drescher, D.G., Recipient, Funding Match for Repair of SPR Instrument, Research and Graduate Programs, School of Medicine, Wayne State University, $3,525.  12/09    

Drescher, D.G.
, Recipient, Funding Match for Repair of SPR Instrument, Office of the Vice President for Research, Wayne State University, $3,500.  12/09

Selected Publications

(last 5 years)

Ramakrishnan NA, Drescher MJ, Morley BJ, Kelley PM, Drescher DG.  Calcium regulates molecular interactions of otoferlin with SNARE proteins required for hair cell exocytosis.  J Biol Chem 289: 8750-8766, 2014.  (PMID: 24478316)

Drescher DG. Identification of the porosome complex in the hair cell. In: Jena, B.P., Taatjes, D.J., NanoCellBiology: Multimodal Imaging in Biology and Medicine, Pan Sanford Publishing Pte. Ltd., 2013.

Selvakumar D, Drescher MJ, Drescher DG. CNGA3 interacts with stereocilia tip-link cadherin 23 +68 or alternatively with myosin viia, two proteins required for hair cell mechanotransduction. J Biol Chem, 2013. doi:10.1074/jbc.M112.443226 (PMID: 23329832)

Selvakumar D, Drescher MJ, Dowdall J, Khan KM, Hatfield JS, Ramakrishnan NA, Drescher DG.  CNGA3 is expressed in inner ear hair cells and binds to an intracellular carboxy terminus domain of EMILIN1. Biochem J 443: 463-476, 2012. doi:10.1042/BJ20111255  (PMID: 22248097)

Ramakrishnan NA, Drescher MJ, Drescher DG. The SNARE complex in neuronal and sensory cells. Mol Cell Neurosci 50: 58-69, 2012.  doi:10.1016/j.mcn.2012.03.009 (PMID: 22498053; PMCID: PMC3570063)

Ramakrishnan NA, Drescher MJ, Khan KM, Hatfield JS, Drescher DG. HCN1 and HCN2 are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2. J Biol Chem 287: 37628-37646, 2012.  doi:10.1074/jbc.M112.375832 (PMID: 22948144; PMCID: PMC3488041)

Drescher DG, Cho WJ, Drescher MJ.  Identification of the porosome complex in the hair cell. Cell Biol Int Rep 18(1):31-34, 2011.  art:e00012. doi: 10.1042/CBR20110005  (PMID: 22348194;  PMCID: PMC3279744)

Drescher MJ, Cho WJ, Folbe AJ, Selvakumar D, Kewson DT, Abu-Hamdan MD, Oh CK, Ramakrishnan NA, Hatfield JS, Khan KM, Anne S, Harpool EC, Drescher DG.  An adenylyl cyclase signaling pathway predicts direct dopaminergic input to vestibular hair cells. Neuroscience 171: 1054-1074, 2010. doi:10.1016/j.neuroscience.2010.09.051 (PMID: 20883745; PMCID: PMC3025754)

Drescher DG, Ramakrishnan NA, Drescher, MJ.  Surface plasmon resonance (SPR) analysis of binding interactions of proteins in inner-ear sensory epithelia. Methods Mol Biol 493: 323-343, 2009. (PMID: 18839357; PMCID: PMC2864718)

Ramakrishnan NA, Drescher MJ, Barretto RL, Beisel  KW, Hatfield JS, Drescher DG. Calcium-dependent binding of HCN1 channel protein to hair cell stereociliary tip-link protein protocadherin 15 CD3. J Biol Chem 284: 3227-3238, 2009. (PMID: 19008224; PMCID: PMC2631981)

Ramakrishnan NA, Drescher MJ, Drescher DG. Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel CaV1.3.  J Biol Chem 284: 1364-1372, 2009. (PMID: 19004828; PMCID: PMC2615516)