School of Medicine

Wayne State University School of Medicine

Financial Support/Grants

Historically, the Department of Otolaryngology has enjoyed relatively high levels of outside funding.  Grants to various faculty members within the department and the most current, ongoing projects are listed below:

Grants-2015

  • Zhengqing Hu - PI.  Wayne State University Grants Plus Grant 01/01/2015-06/30/2016  Generation of functional human hair cells from inner ear progenitors via genome-wide demethylation $100,000 
  • Drescher, D.G., PI, Drescher, M.J., Co-PI, R01, “Identification of Acoustico-Lateralis Transmitters," National Institutes of Health, $1,881,250 (2015: 33rd year)
  • Jinsheng Zhang, Ph.D. PI, Department of Defense, "Targeting TNF-Alpha for Treatment of Blast-Induced Tinnitus" Grant ID:    PR141168, 7/1/15-6/30/18, $1,041,342 

  • Jinsheng Zhang, Ph.D. PI, NIH/NIDCD, "Cochlear Electrical Stimulation to Suppress Tinnitus in Rats" Grant ID: R21 DC014335-01 1/1/15-12/31/16,$420,657

  • Jinsheng Zhang, Ph.D. Co-PI (Bao, PI), Department of Defense, "Developing TNF-Alpha-Mediated Treatment for Blast-Induced Tinnitus" Grant ID: MR130317, 1/15/15-1/14/18, $1,496,233

  • Jinsheng Zhang, Ph.D. PI, Martha Entenmann Tinnitus Research Center Inc, "Assess the calpain inhibitory Gabadur as a potential therapy for noise-induced subjective tinnitus of the severe disabling type”. 4/01/15-3/31/18 $180,000

  • Jinsheng Zhang, Ph.D. PI, Department of Defense. "Parallel human and animal models of blast- and concussion-induced tinnitus and related traumatic brain injury (TBI)" Grant ID: W81XWH-11-2-0031, 01/01/2011-02/28/2015 $1,520,000

Grants-2014

  • Zhenqing Hu, MD, PhD, PI, NIDCD/NIH (1 R01 DC013275) "Regeneration of auditory synaptic contacts using stem cell based approaches" $1,615,000.
  • Ho-Sheng Lin, M.D.  “Office of the Vice President for Research, Bridge Funding, PI, “Identification of Early Marker for Head and Neck Cancer through Antibody Profiling”  $35,000. 
  • Mahdi Shkoukani, M.D.  AAFPRS Leslie Bernstein Resident Research Grant, Faculty Advisor & Co-PI "Biomechanics of the Orbital Floor Fracture" $5000. 2014
  • George H. Yoo, M.D. NCI NIH, 5P50 CA 097248-7, 10%  "SPORE and Head and Neck Cancer; The Molecular Basis of Head and Neck Cancer Biology Treatment and Prevention" CI: G Yoo, (PI: Gregory Wolf, MD) Provide scientific direction and coordination for the implementation and quality control of the study. 1/1/09-12/31/15
  • George H. Yoo, M.D. NCI-Southwest Oncology Group, Wayne State University institutional grant. U10 CA14028 20-10%, CI: G Yoo, (PI: Lawrence Flaherty, M.D.)  Provide leadership of the administrative and scientific functions of SWOG. 1/01/04-12/31/14
  • Drescher, D.G., PI, Drescher, M.J., Co-PI, “Molecular-Functional Comparison of the Dysferlin Membrane Repair Complex with the Otoferlin Synaptic Complex," Jain Foundation, 2014. $121,764
  • Drescher, D.G., Research Stimulation Award, Office of the Vice President for Research, Wayne State University, 2014. $36,000
  • Drescher, D.G., Research Stimulation Award, Research and Graduate Programs, Wayne State University School of Medicine, 2014. $36,000
  • Drescher, D.G., Research Award, Department of Otolaryngology, Wayne State University School of Medicine, 2014. $4,500
  • Drescher, D.G., Research Stimulation Award, Office of the Vice President for Research, Wayne State University, 2013-2014. $52,000
  • JInsheng Zhang, Ph.D. (Co-PI), Dr. Yong Xu (PI), National Science Foundation. "A novel 3-dimensional neural probe technology combining electrical and chemical interfaces" Grant ID: ECCS-1028564, 10/01/2010-09/30/2014, $330,000
  • Jinsheng Zhang, Ph.D. PI, Tinnitus Research Consortium. "Role of the amygdala and its interactions with auditory structures in tinnitus" 07/01/2010-06/30/2014, $297,202

Grants-2013

  • Zhenqing Hu, MD, PhD, PI, The Carls Endowment Trust, "Regeneration of auditory synapses for the treatment of hearing loss in children"   $40,000.
  • Zhenqing Hu, MD, PhD, Co-PI, Wayne State University Grants Plus  "A flexible cochlear implant for high-resolution functional stimulation and for tissue regeneration" (PI: Cheng, Engineering)   $100,000.
  • Ho-Sheng Lin, M.D. Office of the Vice President for Research, Bridge Funding, PI,  “Identification of Early Marker for Head and Neck Cancer through Antibody Profiling”  $35,000.
  • Robert S. Hong, MD, PhD, Department of Otolaryngology at Wayne State University. PI "Electrical suppression of tinnitus with cochlear implants"  
  • Robert S. Hong, MD, PhD, Sonitus Medical Inc., Site Investigator "Evaluation of benefit for treatment of single sided deafness (SSD) between two bone conduction prosthetic devices: osseointegrated implant versus maxilla anchored removable oral appliance ("SoundBite")- Multi-center clinical trial.
  • Robert S. Hong, MD, PhD, Department of Otolaryngology at Wayne State University. PI "Power reflectance measurements of middle ear fluid"
  • Robert S. Hong, MD, PhD, Auris Medical, Site Investigator "Efficacy and Safety of AM-101 in the Treatment of Acute Peripheral Tinnitus 2 (TACTT2)"
  • Robert S. Hong, MD, PhD, Auris Medical, Site Investigator "AM-101 in the Post-Acute Treatment of Peripheral Tinnitus 1. (AMPACT1) – an open-label extension to the TACTT2 study
  • Michael Carron, M.D. and Giancarlo Zuliani, M.D. Co-Investigators. "Use of Cynaoacrylate to Salvage Endotines in Endoscopic Browlifting."  Microaire Corporation.  $3500.00  
  • ​Giancarlo Zuliani, Co-I, “Use of Cyanoacrylate for Improved Stability in Endoscopic Brow Lifting.” MicroAire, 2013, $5000.
  • Edwin M. Monsell, M.D., Ph.D., P-I, extension of Active Hearing Loss in Paget's Disease of Bone, Source of Funds: The Paget Foundation, end date 6-30-12, 1 year extension to support data analysis and preparation for publication. (no salary support) 2012-2013 
  • Drescher, D.G., Research Stimulation Award, Research and Graduate Programs, Wayne State University School of Medicine, 2013. $20,000
  • Jinsheng Zhang, Ph.D. Co-Investigator (Project Leader), Dr. Mark Haacke (PI), WSU Enhancement Award. Center for Traumatic Brain Injury Research (CTBIR), 09/01/2010-08/31/2013, $900,000
  • Jinsheng Zhang, Ph.D. PI, TRI (Tinnitus Research Initiative), Germany. "Treating Tinnitus with Electro-Acupuncture (clinical trial)" 07/01/2010-06/30/2013, $31,414    

Grants-2012

  • Zhenqing Hu, MD, PhDPI, Wayne State University Grants Plus "Generation of inner ear hair cell progenitors via epithelial-to-mesenchymal transition"  $100,000.
  • Edwin M. Monsell, M.D., Ph.D., P-I, Active Hearing Loss in Paget's Disease of Bone, The Paget Foundation, $10,000. 1995-2012  
  • Drescher, M.J., PI, Drescher, D.G., Co-PI, R01, "Adenylyl Cyclase Signaling in Ear Sensory Epithelia," National Institutes of Health, 5/1/05-4/30/12. $1,500,000
  • Jinsheng Zhang, Ph.D. PI, National Institute of Health (NIH)/ National Institute on Deafness and Other Communication Disorders (NIDCD). "Cortical electrical suppression of noise-induced tinnitus" Grant ID: 1R21 DC010059-01, 02/15/2009-01/31/2012, $418,000
  • Jinsheng Zhang, Ph.D. PI, National Institute of Health (NIH)/ National Institute on Deafness and Other Communication Disorders (NIDCD)." Cortical electrical suppression of noise-induced tinnitus (Supplements for purchasing Equipment)". Grant ID: 3R21 DC010059-01S1, 06/01/2009-01/31/2012, $83,245
  • Jinsheng Zhang, Ph.D. (Co-PI), Dr. Sean Wu (PI), President’s Research Enhancement Program in Physical Sciences (WSU). "Tinnitus Diagnosis and Treatment via Innovative Acoustic/Neural Stimulus and Imaging Technologies" 06/15/2011-12/15/2012, $100,000
  • Jinsheng Zhang, Ph.D. Mentor/Sponsor (Jessica Ouyang, Ph.D. student, P.I.). American Association of Nurse Anesthetists Foundation (AANA). "Impact of isoflurance and sevoflurance on cortical activity: in vivo multi-channel electrophysiology studies and implications in monitoring consciousness" 01/01/2010-12/31/2012, $10,000

Grants-2011

  • Ho-Sheng Lin, M.D.  National Cancer Institute  Phase 1 IMAT SBIR,  PA08-050,  1 R43 CA139806-01.  Co-PIs: Nada Khattar and Ho-Sheng Lin  “Autoantibody Profiling for Serological Detection of Head and Neck Cancer”  $206,140 
  • Zhenqing Hu, MD, PhD, PI, NIDCD/NIH (1R03DC011597) "Reconstruction of the ascending neural circuit from the spiral ganglion to the cochlear nucleus in the presence of neurotrophins"  $456,000.  
  • Zhenqing Hu, MD, PhDPI, The Deafness Research Foundation Year 2 Research Grant "Innervation of in vitro-produced hair cell by neural progenitor-derived neurons"  $22,500
  • Zhenqing Hu, MD, PhDPI, The American Hearing Research Foundation Research Grant "Regeneration of the central processes of spiral ganglion neurons using a cell-based replacement"  $20,000
  • Giancarlo Zuliani, M.D. Ethicon surgical grant for Wayne State University Facial Plastics Course, $1000.
  • Robert S. Hong, MD, PhD, Cochlear Americas,  PI, "Cochlear implantation for single-sided deafness- feasibility study"
  • Robert S. Hong, MD, PhD, Michigan Ear Institute. PI "Endolymphatic sac decompression with intra-sac steroids"
  • Giancarlo Zuliani, Ethicon surgical grant for Wayne State University Facial Plastics Course, 2011, $1000. 
  • Ramakrishnan, N.A., PI, Drescher, D.G., Co-PI, “Molecular biology and protein-protein interactions in auditory/vestibular afferent synaptic transmission” Deafness Research Foundation  7/1/11-6/30/11 $25,000.
  • Drescher, D.G., PI, "Research Equipment Maintenance Match”, Wayne State University School of Medicine, $2,000. 10/11
  • Drescher, D.G., PI, Drescher, M.J., Co-PI, R01, ARRA Administrative Supplement, “Identification of Acoustico-Lateralis Transmitters," National Institutes of Health, $106,250.  6/09-5/11

Grants-2010  

  • Ho-Sheng Lin, M.D.  Biomedical Laboratory Research & Development, Service of the VA Office of Research and Development, (BLR&D) MERIT REVIEW AWARD (PARENT I01), I01 BX007080,  PI  “Proteomic Approach for Early Detection of Head and Neck Cancer” $500,000                                   
  • Zhenqing Hu, MD, PhD, PI, The Deafness Research Foundation Year 1 Research Grant "Innervation of In Vitro-produced Hair Cell by Neural Progenitor-derived Glutamatergic Neurons”  $22,500
  • Zhenqing Hu, MD, PhD.  American Academy of Audioloy, “Implantation of Inner Ear-Derived Neural Stem Cells into the Adult Inner Ear", $10,000.  
  • Michael Carron, MD, Giancarlo Zuliani, MD, KLS Martin, “Biomechanical analysis of Absorbable Plate and Screw Fixation of fractures with the Sonic Weld system”, $4,500. 
  • Jinsheng Zhang, PhD, Tinnitus Research Consortium, "Role of the amygdala and its interactions with auditory structures in tinnitus", $297,202.
  • Jinshang Zhang, PhD, Tinnitus Research Initiative, "Treating Tinitus with Electro-Acupuncture (clinical trial)", $31,414
  • George Yoo, MD,  NCI-Southwest Oncology Group (C-I).  NCI cooperative group grant 10%, 1/01/06 - 12/31/10.
  • Giancarlo Zuliani, M.D. KLS Martin, Co-I “Biomechanical analysis of Absorbable Plate and Screw Fixation of fractures with the Sonic Weld system”. $4,300.00  
  • Kelvin Kwong, M.D., Lions Hearing Center of Michigan, "Incidence of Otitis Media and Sensorineural Hearing Loss in Preterm Infants", $2,000.
  • Javan Nation, M.D., Lions Hearing Center of Michigan, "The Effect of Electrical Stimulatino of the Dorsal Cochlear Nucleus on Hearing in Periphally Deafened Animals", $2,000
  • Gregory Kruper, M.D., Lions Hearing Center of Michigan, "Adenoid tissue as a biofilm reservoir in the pathogenesis of chronic rhinosinusitis in children", $2,000.
  • Jinsheng Zhang, Ph.D. Co-Mentor/Sponsor (Na Zhu, PhD. candidate, P.I.). American Tinnitus Association (ATA). "Development of an innovative, 3D computer aided diagnosis system for tinnitus." 01/01/2011-12/31/2011 $10,000

Grants-2009

  • Dennis Drescher, Ph.D., Marian Drescher, Ph.D.-NIH, "Identification of Acoustico-Lateralis Transmitters", $1,500,000.
  • Dennis Drescher, Ph.D.,ARRA supplement, "Identification of Acoustico-Lateralis Transmitters", 7-1-09 to 6-30-11, $161,500.
  • Ho-Sheng Lin, M.D., VA Merit Review/BLR&D Merit Review Award (Parent I01), "Proteomic Approach for Early Detection of Head and Neck Cancer", $200,000.
  • Ho-Sheng Lin, M.D., National Cancer Institute, "Serum and Salivary Immunodiagnostic in Head and Neck Cancer", $150,000.
  • Ho-Sheng Lin, M.D.   National Cancer Institute, IMAT SBIR, PA08-050, 1 R43 CA139806-01, Co-PIs Nada Khattar and Ho-Sheng Lin.  “Autoantibody Profiling for Serological Detection of Head and Neck Cancer”  $206,140
  • Jinsheng Zhang, Ph.D., NIH/NIDCD, "Cortical electrical suppression of noise-induced tinnitus", $413,875.
  • Kelvin Kwong, M.D., American Tinnitus Association, "Mechanisms Underlying Acoustic Masking of Tinnitus", $10,000.
  • George Yoo, M.D., NCI-Southwest Oncology Group (C-I), Provide Surgical leadership of the administrative and scientific functions of SWOG, 1/01/04 - 12/31/09, $38,881.
  • James Kaltenbach, Ph.D., Paul Finlayson,Ph.D., NIDCD (R01), "Central Auditory plasticity as a basis of tinnitus", $62,354.
  • Paul Finlayson,Ph.D., American Tinnitus Association, "Noise-induced tinnitus: DCN hyperactivity and the cyclic-AMP pathway: Biophysical Properties.  $49,954.
  • Jinsheng Zhang, PhD, NIH/NIDCD, "Cortical Electrical Suppression of Noise-Induced Tinnitus (EQ Equipment supplements)", $83,245.
  • Jessica Quyang (PhD student), Jinsheng Zhang (Sponsor), The American Association of Nurse Anethestists Foundation, "Impact of isoflurance and sevoflurance on cortical activity: in vivo multi-channel electrophysiology studies and implications in monitoring consciousness, $10,000.