Financial Support/Grants

Historically, the Department of Otolaryngology has enjoyed relatively high levels of outside funding.  Grants to various faculty members within the department and the most current, ongoing projects are listed below.

WSU medical resident wins grant to explore salivary method for diagnosing common esophageal disease

https://today.wayne.edu/medicine/news/2021/12/01/wsu-medical-resident-wins-grant-to-explore-salivary-method-for-diagnosing-common-esophageal-disease-46578

  • 2019

    Ho-Sheng Lin, M.D., Site PI, (J Zhang, main PI) Department of Defense/CDMRP, "Clinical Trial of Etanercept (TNF-alpha Blocker) for Treatment of Blast-Induced Tinnitus"  9/30/2018-09/29/2022  $355,434. 

    Drescher, D.G., Ph.D., PI, Drescher, M.J., Ph.D., Co-PI, “Molecular-Functional Comparison of the Dysferlin Membrane Repair Complex with the Otoferlin Synaptic Complex,” Jain Foundation, 6/1/19-5/31/20  $106,864

    Jinsheng Zhang, Ph.D. Co-PI, (Altschuler, PI)  Department of Defense, "Mechanism Based Prevention of Noise-Induced Tinnitus: Protection and Repair of Peripheral Auditory Neuropathy" 09/30/2017-09/29/2020, $1,507,849

    Zhengqing Hu, Ph.D., PI, “Developing novel stem cell-based epigenetic approaches to treat hearing loss”  Veterans Affairs Merit Review (Parent I01), 10/2018-09/2022,  $1,100,000

    Zhengqing Hu, Ph.D., PI, “Regeneration of auditory synaptic contacts using stem cell based approaches”  NIH/NIDCD (Parent R01), 05/2014-04/2020,  $1,062,500

    Jinsheng Zhang, Ph.D., PI.  Department of Defense/CDMRP, "Clinical Trial of Etanercept (TNF-alpha Blocker) for Treatment of Blast-Induced Tinnitus"  9/30/2018-09/29/2022  $8,651,782 

    Jinsheng Zhang, Ph.D. PI.  Department of Defense/CDMRP, "Targeting TNF-Alpha for Treatment of Blast-Induced Tinnitus"  09/30/2015-09/29/2019  $1,499,107

    Hao Luo, Ph.D.,PI “Cochlear electrical stimulation induced tinnitus suppression and related neural activity change in the rat’s inferior colliculus.” Hearing Health Foundation, 07/01/2019-06/30/2020, $29,959

  • 2018

    Zhengqing Hu - PI.  Veterans Affairs Merit Review (Parent I01) (I01 RX0021000)  "Developing novel stem cell-based epigenetic approaches to treat hearing loss"  12/2017-11/2021  $1,100,000

    Dennis G. Drescher, PI, Marian J Drescher, Co-PI, "Molecular-Functional Comparison of the Dysferlin Membrane Repair Complex with the Otoferlin Synaptic Complex," Jain Foundation, 10/1/17-3/31/19 Funded $117,384

    Jinsheng Zhang, Ph.D. Co-PI, (Altschuler, Holt, PIs)  Department of Defense, "Mechanism Based Prevention of Noise-Induced Tinnitus: Protection and Repair of Peripheral Auditory Neuropathy" 09/30/2017-09/29/2020, $1,507,849

    Zhengqing Hu - PI.  NIDCD/NIH (1R01DC013275)  "Regeneration of auditory synaptic contacts using stem cell based approaches" 05/2014-04/2019, $1,062,500 

    Jinsheng Zhang, Ph.D. PI.  Department of Defense/CDMRP, "Targeting TNF-Alpha for Treatment of Blast-Induced Tinnitus"  09/30/2015-09/29/2019  $1,499,107

    Jinsheng Zhang, Ph.D. Co-PI, (Bao, PI).  Department of Defense/CDMRP, "Developing TNF-Alpha-Mediated Treatment for Blast-Induced Tinnitus"  01/15/2015-01/14/2019  $1,496,233

  • 2017

    Drescher, D.G., PI, Drescher, M.J., Co-PI, "Molecular-Functional Comparison of the Dysferlin Membrane Repair Complex with the Otoferlin Synaptic Complex," Jain Foundation, 10/1/17-9/30/18      117,384

    Jinsheng Zhang, Ph.D. Co-PI, (Altschuler, PI)  Departmentof Defense, "Mechanism Based Prevention of Noise-Induced Tinnitus: Protection and Repair of Peripheral Auditory Neuropathy" 09/30/2017-09/29/2020, $1,507,849

    Zhengqing Hu - PI.  NIDCD/NIH (1R01DC013275)  "Regeneration of auditory synaptic contacts using stem cell based approaches" 05/2014-04/2019, $1,062,500 

    Zhengqing Hu - PI.  Veterans Affairs Merit Review (Parent I01) (I01 RX0021000)  "Developing novel stem cell-based epigenetic approaches to treat hearing loss"  12/2017-11/2021  $1,100,000 

    Jinsheng Zhang, Ph.D. PI.  Martha Entenmann Tinnitus Research Center, Inc.  "Assess the calpain inhibitory Gabadur as a potential therapy for noise-induced subjective tinnitus of the severe disabling type”.  04/01/2015-03/31/2018  $180,000 

    Zhengqing Hu - PI.  Wayne State University Grants Plus Grant  "Generation of functional human hair cells from inner ear progenitors via genome-wide demethylation"  03/2015-11/2017  $100,000 

  • 2016

    Drescher, D.G., PI, Drescher, M.J., Co-PI, "Molecular-Functional Comparison of the Dysferlin Membrane Repair Complex with the Otoferlin Synaptic Complex," Jain Foundation, 2016-2017  $119,734

    Jinsheng Zhang, Ph.D. PI.  Martha Entenmann Tinnitus Research Center, Inc.  "Assess the calpain inhibitory Gabadur as a potential therapy for noise-induced subjective tinnitus of the severe disabling type”.  04/01/2015-03/31/2018  $180,000 

    Jinsheng Zhang, Ph.D. PI, Department of Defense, "Targeting TNF-Alpha for Treatment of Blast-Induced Tinnitus" Grant ID:  PR141168, 7/2015-6/2018, $1,499,107 

    Jinsheng Zhang, Ph.D. Co-I (Bao, PI), Department of Defense, "Developing TNF-Alpha-Mediated Treatment for Blast-Induced Tinnitus" Grant ID: MR130317, 1/2015-1/2018, $1,496,233

    Zhengqing Hu - PI.  Wayne State University Grants Plus Grant  "Generation of functional human hair cells from inner ear progenitors via genome-wide demethylation"  03/2015-11/2017  $100,000 

  • 2015

    Zhengqing Hu - PI.  Wayne State University Grants Plus Grant  "Generation of functional human hair cells from inner ear progenitors via genome-wide demethylation"  03/2015-11/2017  $100,000 

    Drescher, D.G., PI, Drescher, M.J., Co-PI, R01, "Identification of Acoustico-Lateralis Transmitters," National Institutes of Health, $1,881,250 (2015: 33rd year)

    Drescher, D.G., PI, Drescher, M.J., Co-PI, "Molecular-Functional Comparison of the Dysferlin Membrane Repair Complex with the Otoferlin Synaptic Complex," Jain Foundation, 2015-2016  $121,764

    Jinsheng Zhang, Ph.D. PI, Department of Defense, "Targeting TNF-Alpha for Treatment of Blast-Induced Tinnitus" Grant ID:  PR141168, 7/2015-6/2018, $1,499,107 

    Jinsheng Zhang, Ph.D. PI, NIH/NIDCD, "Cochlear Electrical Stimulation to Suppress Tinnitus in Rats" Grant ID: R21 DC014335-01 1/2015-12/2016, $420,657

    Jinsheng Zhang, Ph.D. Co-I (Bao, PI), Department of Defense, "Developing TNF-Alpha-Mediated Treatment for Blast-Induced Tinnitus" Grant ID: MR130317, 1/2015-1/2018, $1,496,233

    Jinsheng Zhang, Ph.D. PI, Martha Entenmann Tinnitus Research Center Inc, "Assess the calpain inhibitory Gabadur as a potential therapy for noise-induced subjective tinnitus of the severe disabling type". 4/205-3/208, $180,000

    George Yoo, M.D. Co-I (Gregory Wolf, M.D.-PI) NCI NIH, 5P50 CA 097248-7, 10%  "SPORE and Head and Neck Cancer; The Molecular Basis of Head and Neck Cancer Biology Treatment and Prevention" 1/2009-12/2015 

  • 2014

    Zhenqing Hu, MD, PhD, PI, NIDCD/NIH (1 R01 DC013275) "Regeneration of auditory synaptic contacts using stem cell based approaches" $1,615,000.

    Ho-Sheng Lin, M.D.  "Office of the Vice President for Research, Bridge Funding, PI, "Identification of Early Marker for Head and Neck Cancer through Antibody Profiling"  $35,000. 

    Mahdi Shkoukani, M.D.  AAFPRS Leslie Bernstein Resident Research Grant, Faculty Advisor & Co-PI "Biomechanics of the Orbital Floor Fracture" $5000. 2014

    George H. Yoo, M.D. NCI NIH, 5P50 CA 097248-7, 10%  "SPORE and Head and Neck Cancer; The Molecular Basis of Head and Neck Cancer Biology Treatment and Prevention" CI: G Yoo, (PI: Gregory Wolf, MD) Provide scientific direction and coordination for the implementation and quality control of the study. 1/1/09-12/31/15

    George H. Yoo, M.D. NCI-Southwest Oncology Group, Wayne State University institutional grant. U10 CA14028 20-10%, CI: G Yoo, (PI: Lawrence Flaherty, M.D.)  Provide leadership of the administrative and scientific functions of SWOG. 1/2004-12/2014

    Drescher, D.G., PI, Drescher, M.J., Co-PI, "Molecular-Functional Comparison of the Dysferlin Membrane Repair Complex with the Otoferlin Synaptic Complex," Jain Foundation, 2014. $121,764

    Drescher, D.G., Research Stimulation Award, Office of the Vice President for Research, Wayne State University, 2014. $36,000

    Drescher, D.G., Research Stimulation Award, Research and Graduate Programs, Wayne State University School of Medicine, 2014. $36,000

    Drescher, D.G., Research Award, Department of Otolaryngology, Wayne State University School of Medicine, 2014. $4,500

    Drescher, D.G., Research Stimulation Award, Office of the Vice President for Research, Wayne State University, 2013-2014. $52,000

    JInsheng Zhang, Ph.D. (Co-PI), Dr. Yong Xu (PI), National Science Foundation. "A novel 3-dimensional neural probe technology combining electrical and chemical interfaces" Grant ID: ECCS-1028564, 10/2010-09/2014, $330,000

    Jinsheng Zhang, Ph.D. PI, Tinnitus Research Consortium. "Role of the amygdala and its interactions with auditory structures in tinnitus" 07/2010-06/2014, $297,202

  • 2013

    Zhenqing Hu, MD, PhD, PI, The Carls Endowment Trust, "Regeneration of auditory synapses for the treatment of hearing loss in children"   $40,000.

    Zhenqing Hu, MD, PhD, Co-PI, Wayne State University Grants Plus  "A flexible cochlear implant for high-resolution functional stimulation and for tissue regeneration" (PI: Cheng, Engineering)   $100,000.

    Ho-Sheng Lin, M.D. Office of the Vice President for Research, Bridge Funding, PI,  "Identification of Early Marker for Head and Neck Cancer through Antibody Profiling"  $35,000.

    Ho-Sheng Lin, M.D.  Biomedical Laboratory Research & Development service of the VA Office of Research and Development, PI.  "Proteomic Approach for Early Detection of Head and Neck Cancer" $500,000.

    Robert S. Hong, MD, PhD, Sonitus Medical Inc., Site Investigator "Evaluation of benefit for treatment of single sided deafness (SSD) between two bone conduction prosthetic devices: osseointegrated implant versus maxilla anchored removable oral appliance ("SoundBite")- Multi-center clinical trial.

    Michael Carron, M.D. and Giancarlo Zuliani, M.D. Co-Investigators. "Use of Cynaoacrylate to Salvage Endotines in Endoscopic Browlifting."  Microaire Corporation.  $3500.00  

    ​Giancarlo Zuliani, Co-I, "Use of Cyanoacrylate for Improved Stability in Endoscopic Brow Lifting." MicroAire, 2013, $5000.

    Edwin M. Monsell, M.D., Ph.D., P-I, extension of Active Hearing Loss in Paget's Disease of Bone, Source of Funds: The Paget Foundation, end date 6-30-12, 1 year extension to support data analysis and preparation for publication. (no salary support) 2012-2013 

    Drescher, D.G., Research Stimulation Award, Research and Graduate Programs, Wayne State University School of Medicine, 2013. $20,000

    Drescher, D.G., Research Stimulation Award, Office of the Vice President for Research, Wayne State University, 2013-2014. $52,000

    Jinsheng Zhang, Ph.D. Co-Investigator (Project Leader), Dr. Mark Haacke (PI), WSU Enhancement Award. Center for Traumatic Brain Injury Research (CTBIR), 09/01/2010-08/31/2013, $900,000

    Jinsheng Zhang, Ph.D. PI, TRI (Tinnitus Research Initiative), Germany. "Treating Tinnitus with Electro-Acupuncture (clinical trial)" 07/2010-06/2013, $31,414    

  • 2012

    Zhenqing Hu, MD, PhD, PI, Wayne State University Grants Plus "Generation of inner ear hair cell progenitors via epithelial-to-mesenchymal transition"  $100,000.

    Edwin M. Monsell, M.D., Ph.D., P-I, Active Hearing Loss in Paget's Disease of Bone, The Paget Foundation, $10,000. 1995-2012  

    Drescher, M.J., PI, Drescher, D.G., Co-PI, R01, "Adenylyl Cyclase Signaling in Ear Sensory Epithelia," National Institutes of Health, 5/2005-4/2012. $1,500,000

    Jinsheng Zhang, Ph.D. PI, National Institute of Health (NIH)/ National Institute on Deafness and Other Communication Disorders (NIDCD). "Cortical electrical suppression of noise-induced tinnitus" Grant ID: 1R21 DC010059-01, 02/2009-1/2012, $418,000

    Jinsheng Zhang, Ph.D. PI, National Institute of Health (NIH)/ National Institute on Deafness and Other Communication Disorders (NIDCD)." Cortical electrical suppression of noise-induced tinnitus (Supplements for purchasing Equipment)". Grant ID: 3R21 DC010059-01S1, 06/2009-01/2012, $83,245

    Jinsheng Zhang, Ph.D. (Co-PI), Dr. Sean Wu (PI), President's Research Enhancement Program in Physical Sciences (WSU). "Tinnitus Diagnosis and Treatment via Innovative Acoustic/Neural Stimulus and Imaging Technologies" 06/2011-12/2012, $100,000

    Jinsheng Zhang, Ph.D. Mentor/Sponsor (Jessica Ouyang, Ph.D. student, P.I.). American Association of Nurse Anesthetists Foundation (AANA). "Impact of isoflurance and sevoflurance on cortical activity: in vivo multi-channel electrophysiology studies and implications in monitoring consciousness" 01/2010-12/2012, $10,000

    Edwin Monsell, M.D., Ph.D. P-I, extension of Active Hearing Loss in Paget's Disease of Bone, Source of Funds: The Paget Foundation, end date 6-30-12, 2012-2013 1-year extension to support data analysis and preparation for publication. (no salary support) 

  • 2011

    Jinsheng Zhang, Ph.D. PI, Department of Defense. "Parallel human and animal models of blast- and concussion-induced tinnitus and related traumatic brain injury (TBI)" Grant ID: W81XWH-11-2-0031, 01/2011-02/2015 $1,520,000

    Ho-Sheng Lin, M.D.  National Cancer Institute  Phase 1 IMAT SBIR,  PA08-050,  1 R43 CA139806-01.  Co-PIs: Nada Khattar and Ho-Sheng Lin  "Autoantibody Profiling for Serological Detection of Head and Neck Cancer"  $206,140 

    Zhenqing Hu, MD, PhD, PI, The Deafness Research Foundation Year 2 Research Grant "Innervation of in vitro-produced hair cell by neural progenitor-derived neurons"  $22,500

    Zhenqing Hu, MD, PhD, PI, The American Hearing Research Foundation Research Grant "Regeneration of the central processes of spiral ganglion neurons using a cell-based replacement"  $20,000

    Giancarlo Zuliani, M.D. Ethicon surgical grant for Wayne State University Facial Plastics Course, $1000.

    Robert S. Hong, MD, PhD, Cochlear Americas,  PI, "Cochlear implantation for single-sided deafness- feasibility study" $13,718

    Robert S. Hong, MD, PhD, Michigan Ear Institute. PI "Endolymphatic sac decompression with intra-sac steroids"

    Giancarlo Zuliani,M.D., Ethicon surgical grant for Wayne State University Facial Plastics Course, 2011, $1000. 

    Ramakrishnan, N.A., PI, Drescher, D.G., Co-PI, "Molecular biology and protein-protein interactions in auditory/vestibular afferent synaptic transmission" Deafness Research Foundation  2011 $25,000.

    Drescher, D.G., PI, "Research Equipment Maintenance Match", Wayne State University School of Medicine, $2,000. 10/11

    Drescher, D.G., PI, Drescher, M.J., Co-PI, R01, ARRA Administrative Supplement, "Identification of Acoustico-Lateralis Transmitters," National Institutes of Health, $106,250.  6/09-5/11

  • 2010

    Ho-Sheng Lin, M.D.  Biomedical Laboratory Research & Development, Service of the VA Office of Research and Development, (BLR&D) MERIT REVIEW AWARD (PARENT I01), I01 BX007080,  PI  "Proteomic Approach for Early Detection of Head and Neck Cancer" $500,000                                   

    Zhenqing Hu, MD, PhD, PI, The Deafness Research Foundation Year 1 Research Grant "Innervation of In Vitro-produced Hair Cell by Neural Progenitor-derived Glutamatergic Neurons"  $22,500

    Zhenqing Hu, MD, PhD.  American Academy of Audioloy, "Implantation of Inner Ear-Derived Neural Stem Cells into the Adult Inner Ear", $10,000.  

    Michael Carron, MD, Giancarlo Zuliani, MD, KLS Martin, "Biomechanical analysis of Absorbable Plate and Screw Fixation of fractures with the Sonic Weld system", $4,500. 

    Jinsheng Zhang, PhD, Tinnitus Research Consortium, "Role of the amygdala and its interactions with auditory structures in tinnitus", $297,202.

    Jinshang Zhang, PhD, Tinnitus Research Initiative, "Treating Tinitus with Electro-Acupuncture (clinical trial)", $31,414

    George Yoo, MD,  NCI-Southwest Oncology Group (C-I).  NCI cooperative group grant 10%, 1/2006-12/2010.

    Giancarlo Zuliani, M.D. KLS Martin, Co-I "Biomechanical analysis of Absorbable Plate and Screw Fixation of fractures with the Sonic Weld system". $4,300.00  

    Kelvin Kwong, M.D., Lions Hearing Center of Michigan, "Incidence of Otitis Media and Sensorineural Hearing Loss in Preterm Infants", $2,000.

    Javan Nation, M.D., Lions Hearing Center of Michigan, "The Effect of Electrical Stimulatino of the Dorsal Cochlear Nucleus on Hearing in Periphally Deafened Animals", $2,000

    Gregory Kruper, M.D., Lions Hearing Center of Michigan, "Adenoid tissue as a biofilm reservoir in the pathogenesis of chronic rhinosinusitis in children", $2,000.

    Jinsheng Zhang, Ph.D. Co-Mentor/Sponsor (Na Zhu, PhD. candidate, P.I.). American Tinnitus Association (ATA). "Development of an innovative, 3D computer aided diagnosis system for tinnitus." 01/2011-12/2011 $10,000

  • 2009

    Dennis Drescher, Ph.D., Marian Drescher, Ph.D.-NIH, "Identification of Acoustico-Lateralis Transmitters", $1,500,000.

    Dennis Drescher, Ph.D.,ARRA supplement, "Identification of Acoustico-Lateralis Transmitters", 7-1-09 to 6-30-11, $161,500.

    Ho-Sheng Lin, M.D., VA Merit Review/BLR&D Merit Review Award (Parent I01), "Proteomic Approach for Early Detection of Head and Neck Cancer", $200,000.

    Ho-Sheng Lin, M.D., National Cancer Institute, "Serum and Salivary Immunodiagnostic in Head and Neck Cancer", $150,000.

    Ho-Sheng Lin, M.D.   National Cancer Institute, IMAT SBIR, PA08-050, 1 R43 CA139806-01, Co-PIs Nada Khattar and Ho-Sheng Lin.  "Autoantibody Profiling for Serological Detection of Head and Neck Cancer"  $206,140

    Jinsheng Zhang, Ph.D., NIH/NIDCD, "Cortical electrical suppression of noise-induced tinnitus", $413,875.

    Kelvin Kwong, M.D., American Tinnitus Association, "Mechanisms Underlying Acoustic Masking of Tinnitus", $10,000.

    George Yoo, M.D., NCI-Southwest Oncology Group (C-I), Provide Surgical leadership of the administrative and scientific functions of SWOG, 1/2004 - 12/2009, $38,881.

    James Kaltenbach, Ph.D., Paul Finlayson,Ph.D., NIDCD (R01), "Central Auditory plasticity as a basis of tinnitus", $62,354.

    Paul Finlayson,Ph.D., American Tinnitus Association, "Noise-induced tinnitus: DCN hyperactivity and the cyclic-AMP pathway: Biophysical Properties.  $49,954.

    Jinsheng Zhang, PhD, NIH/NIDCD, "Cortical Electrical Suppression of Noise-Induced Tinnitus (EQ Equipment supplements)", $83,245.

    Jessica Quyang (PhD student), Jinsheng Zhang (Sponsor), The American Association of Nurse Anethestists Foundation, "Impact of isoflurance and sevoflurance on cortical activity: in vivo multi-channel electrophysiology studies and implications in monitoring consciousness, $10,000.

    Edwin Monsell, M.D., Ph.D., P-I, The Paget Foundation "Active Hearing Loss in Paget's Disease of Bone" 1995-2012  $10,000